Three-Dimensional Stiff Graphene Scaffold on Neural Stem Cells Behavior
文献类型：期刊论文
| 作者 | Ma, Qinqin(马勤勤); Yang, Lingyan(杨令延); Jiang, Ziyun(姜自云); Song, Qin(宋琴); Xiao, Miao(肖淼); Zhang, Dong; Ma, Xun; Wen, Tieqiao; Cheng, Guosheng(程国胜) |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:50 |
| 通讯作者 | Cheng, Guosheng(程国胜) |
| 英文摘要 | Physical cues of the scaffolds, elasticity, and stiffness significantly guide adhesion, proliferation, and differentiation of stem cells. In addressable microenvironments constructed by three-dimensional graphene foams (3D-GFs), neural stem cells (NSCs) interact with and respond to the structural geometry and mechanical properties of porous scaffolds. Our studies aim to investigate NSC behavior on the various stiffness of 3D-GFs. Two kinds of 3D-GFs scaffolds present soft and stiff properties with elasticity moduli of 30 and 64 kPa, respectively. Stiff scaffold enhanced NSC attachment and proliferation with vinculin and integrin gene expression were up-regulated by 2.3 and 1.5 folds, respectively, compared with the soft one. Meanwhile, up-regulated Ki67 expression and almost no variation of nestin expression in a group of the stiff scaffold were observed, implying that the stiff substrate fosters NSC growth and keeps the cells in an active stem state. Furthermore, NSCs grown on stiff scaffold exhibited enhanced differentiation to astrocytes. Interestingly, differentiated neurons on stiff scaffold are suppressed since growth associated protein-43 expression was significantly improved by 5.5 folds. |
| 关键词[WOS] | CENTRAL-NERVOUS-SYSTEM ; MECHANICAL-PROPERTIES ; FOCAL ADHESIONS ; GROWTH-FACTOR ; SUBSTRATE ; DIFFERENTIATION ; MATRIX ; IDENTIFICATION ; PROLIFERATION ; TOPOGRAPHY |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000390728900008 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4752]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_程国胜团队 |
| 推荐引用方式 GB/T 7714 | Ma, Qinqin,Yang, Lingyan,Jiang, Ziyun,et al. Three-Dimensional Stiff Graphene Scaffold on Neural Stem Cells Behavior[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(50). |
| APA | Ma, Qinqin.,Yang, Lingyan.,Jiang, Ziyun.,Song, Qin.,Xiao, Miao.,...&Cheng, Guosheng.(2016).Three-Dimensional Stiff Graphene Scaffold on Neural Stem Cells Behavior.ACS APPLIED MATERIALS & INTERFACES,8(50). |
| MLA | Ma, Qinqin,et al."Three-Dimensional Stiff Graphene Scaffold on Neural Stem Cells Behavior".ACS APPLIED MATERIALS & INTERFACES 8.50(2016). |
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