Functional Hyperbranched Polylysine as Potential Contrast Agent Probes for Magnetic Resonance Imaging
文献类型：期刊论文
| 作者 | Zu, GY; Liu, M(刘敏); Zhang, KC(张坤驰); Hong, SN; Dong, JJ; Cao, Y; Jiang, B; Luo, LQ; Pei, RJ(裴仁军) |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2016 |
| 卷号 | 17期号:6 |
| 通讯作者 | Pei, RJ(裴仁军) |
| 英文摘要 | Researchers have never stopped questing contrast agents with high resolution and safety to overcome the drawbacks of small-molecule contrast agents in clinic. Herein, we reported the synthesis of gadolinium-based hyperbranched polylysine (HBPLL-DTPA-Gd), which was prepared by thermal polymerization of L-lysine via one-step polycondensation. After conjugating with folic acid, its potential application as MRI contrast agent was then evaluated. This contrast agent had no obvious cytotoxicity as verified by WST assay and H&E analysis. Compared to Gd(III)-diethylenetriamine-pentaacetic acid (Gd-DTPA) (r(1) = 4.3 mM(-1) s(-1)), the FA-HBPLL-DTPA-Gd exhibited much higher longitudinal relaxivity value (r(1) = 13.44 mM(-1) s(-1)), up to 3 times higher than Gd-DTPA. The FA-HBPLL-DTPA-Gd showed significant signal intensity enhancement in the tumor region at various time points and provided a long time window for MR examination. The results illustrate that FA-HBPLL-DTPA-Gd will be a potential candidate for tumor-targeted MRI. |
| 关键词[WOS] | DENDRITIC POLYMERS ; MRI ; DENDRIMERS ; CANCER ; NANOPARTICLES ; BREAST ; TUMORS ; CORES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377924800043 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4522]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_裴仁军团队 |
| 推荐引用方式 GB/T 7714 | Zu, GY,Liu, M,Zhang, KC,et al. Functional Hyperbranched Polylysine as Potential Contrast Agent Probes for Magnetic Resonance Imaging[J]. BIOMACROMOLECULES,2016,17(6). |
| APA | Zu, GY.,Liu, M.,Zhang, KC.,Hong, SN.,Dong, JJ.,...&Pei, RJ.(2016).Functional Hyperbranched Polylysine as Potential Contrast Agent Probes for Magnetic Resonance Imaging.BIOMACROMOLECULES,17(6). |
| MLA | Zu, GY,et al."Functional Hyperbranched Polylysine as Potential Contrast Agent Probes for Magnetic Resonance Imaging".BIOMACROMOLECULES 17.6(2016). |
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