Biocleavable Oligolysine-Grafted Poly(disulfide amine)s as Magnetic Resonance Imaging Probes
文献类型：期刊论文
| 作者 | Dong, JJ(董京金); Liu, M(刘敏); Zhang, KC(张坤驰); Cao, Y(曹翼); Jiang, B(姜斌); Zu, GY(祖广月); Pei, RJ(裴仁军) |
| 刊名 | BIOCONJUGATE CHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 27期号:1 |
| 通讯作者 | Pei, RJ(裴仁军) |
| 英文摘要 | To develop safe and effective macromolecular MRI contrast agents, a macromolecular contrast agent (mCA) containing biocleavable disulfide bonds in the main chain and oligolysine in the side chain is prepared, and its applicability as a MRI contrast agent is demonstrated both in vitro and in vivo. This brush-like mCA possesses a high T-1 relaxivity (11.8 mM(-1) s(-1)), up to 3 times higher than the commercial Gd-DTPA (4.2 mM(-1) s(-1)), along with very low toxicity as determined by WST assay and histological analysis. Meanwhile, the disulfide bond can be broken under appropriate reducing conditions, followed by degradation into small fragments. Furthermore, the mCA is functionalized with folic acid to improve the target specificity. In vivo experiments show that FA-labeled mCA can efficiently enhance the resolution between the tumor and surrounding tissues compared to the mCA without FA. This study may provide helpful insights for the further development of sensitive and biocompatible MRI probes. |
| 关键词[WOS] | MRI CONTRAST AGENTS ; IN-VIVO ; NANOPARTICLES ; CHEMISTRY ; CANCER ; BIODEGRADATION ; RELAXIVITY ; DENDRIMERS ; COMPLEXES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000368651600017 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4892]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_裴仁军团队 |
| 推荐引用方式 GB/T 7714 | Dong, JJ,Liu, M,Zhang, KC,et al. Biocleavable Oligolysine-Grafted Poly(disulfide amine)s as Magnetic Resonance Imaging Probes[J]. BIOCONJUGATE CHEMISTRY,2016,27(1). |
| APA | Dong, JJ.,Liu, M.,Zhang, KC.,Cao, Y.,Jiang, B.,...&Pei, RJ.(2016).Biocleavable Oligolysine-Grafted Poly(disulfide amine)s as Magnetic Resonance Imaging Probes.BIOCONJUGATE CHEMISTRY,27(1). |
| MLA | Dong, JJ,et al."Biocleavable Oligolysine-Grafted Poly(disulfide amine)s as Magnetic Resonance Imaging Probes".BIOCONJUGATE CHEMISTRY 27.1(2016). |
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