Efficient cancer ablation by combined photothermal and enhanced chemo-therapy based on carbon nanoparticles/doxorubicin@SiO2 nanocomposites
文献类型：期刊论文
| 作者 | Tu, XL; Wang, LN; Cao, YH; Ma, YF; Shen, H; Zhang, MX(张萌欣); Zhang, ZJ(张智军) |
| 刊名 | CARBON
 |
| 出版日期 | 2016 |
| 卷号 | 97 |
| 通讯作者 | Zhang, ZJ(张智军) |
| 英文摘要 | The combination of different treatments in cancer therapy has drawn massive attention in the last decades due to its superior anticancer ability to single treatment. One of the most useful strategies to achieve this purpose is to design and construct efficient multifunctional nanoplatforms. Here we report our effort in development of carbon nanoparticles/doxorubicin@SiO2 nanocomposites and their application for combined photothermal and chemotherapy in cancer ablation. The nanocomposites are obtained via reverse microemulsion method with controlled size and high drug loading ratio. These nanocomposites possess high heat-generating ability, pH responsive drug delivery, and heat-induced high drug release as well. In vitro experiment reveals that the combined photothermal and chemotherapy exhibits much higher toxicity to 4T1 cells than photothermal therapy or chemotherapy alone. In vivo experiment reveals that compared with single treatment, the combined photothermal and chemo-therapy can effectively inhibit tumor growth and destroy it eventually without cancer recurrence. The current research demonstrates that carbon nanoparticles/doxorubicin@SiO2 nanocomposites can be used as an efficient nanoplatform for combined cancer photothermal and chemo-therapy. (C) 2015 Elsevier Ltd. All rights reserved. |
| 关键词[WOS] | PEGYLATED GRAPHENE OXIDE ; SILICA-COATED GOLD ; IN-VIVO ; THERANOSTIC PLATFORM ; QUANTUM DOTS ; NANOPARTICLES ; NANOTUBES ; COMBINATION ; TOXICITY ; LIGHT |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366939900004 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4694]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队 |
| 推荐引用方式 GB/T 7714 | Tu, XL,Wang, LN,Cao, YH,et al. Efficient cancer ablation by combined photothermal and enhanced chemo-therapy based on carbon nanoparticles/doxorubicin@SiO2 nanocomposites[J]. CARBON,2016,97. |
| APA | Tu, XL.,Wang, LN.,Cao, YH.,Ma, YF.,Shen, H.,...&Zhang, ZJ.(2016).Efficient cancer ablation by combined photothermal and enhanced chemo-therapy based on carbon nanoparticles/doxorubicin@SiO2 nanocomposites.CARBON,97. |
| MLA | Tu, XL,et al."Efficient cancer ablation by combined photothermal and enhanced chemo-therapy based on carbon nanoparticles/doxorubicin@SiO2 nanocomposites".CARBON 97(2016). |
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