Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells
文献类型：期刊论文
| 作者 | Chen, Hao; Wang, Lina; Fu, Han; Wang, Zhiying; Xie, Yujie; Zhang, Zhijun(张智军); Tang, Yu |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2016 |
| 卷号 | 4期号:46 |
| 通讯作者 | Tang, Y ; Zhang, Zhijun(张智军) |
| 英文摘要 | The development of multimodal nanoprobes is of great importance in nanomedicine because it integrates the advantages of each imaging modality and offers a significantly enhanced diagnostic effect. In this work, gadolinium(III) functionalized fluorescent carbon dots (Gd-CDs) are synthesized by means of a one-step hydrothermal approach. As a fluorescent nanomaterial, the obtained Gd-CDs exhibit strong and stable fluorescence with excitation-independent emission behavior. Moreover, as an MRI contrast agent, the Gd-CDs exhibited a longitudinal relaxation rate of 6.06 mM(-1) s(-1), which is significantly higher than that of the commercially available MRI agent Gadovist (4.24 mM(-1) s(-1)). In addition, the cellular experiment reveals that Gd-CDs promote the proliferation of human mesenchymal stem cells (hMSCs), which is tracked by the fluorescence/Magnetic Resonance dual-modality imaging of hMSCs by the Gd-CDs. |
| 关键词[WOS] | GRAPHENE QUANTUM DOTS ; NEPHROGENIC SYSTEMIC FIBROSIS ; MRI CONTRAST AGENTS ; IN-VIVO ; SURFACE-STATE ; ENDOTHELIAL-CELLS ; CANCER-THERAPY ; DRUG-DELIVERY ; NANODOTS ; FLUORESCENT |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000389666000015 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4922]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队 |
| 推荐引用方式 GB/T 7714 | Chen, Hao,Wang, Lina,Fu, Han,et al. Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(46). |
| APA | Chen, Hao.,Wang, Lina.,Fu, Han.,Wang, Zhiying.,Xie, Yujie.,...&Tang, Yu.(2016).Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells.JOURNAL OF MATERIALS CHEMISTRY B,4(46). |
| MLA | Chen, Hao,et al."Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells".JOURNAL OF MATERIALS CHEMISTRY B 4.46(2016). |
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