915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes
文献类型：期刊论文
| 作者 | Huang, YA(皇亚楠); Xiao, QB(肖清波); Hu, HS(胡慧珊); Zhang, KC(张坤驰); Feng, YM(封雅敏); Li, FJ(李付锦); Wang, J(王健); Ding, XG(丁显光); Jiang, J(姜江); Li, YF |
| 刊名 | SMALL
 |
| 出版日期 | 2016 |
| 卷号 | 12期号:31 |
| 通讯作者 | Xiao, QB(肖清波) ; Lin, HZ(蔺洪振) |
| 英文摘要 | Lanthanide (Ln(3+))-doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na0.52YbF3.52:Er UCNPs of high luminescence intensity and color purity are synthesized via a facile solvothermal method. The red UC emission from the present nanophosphors is three times more intense than the well-known green emission from the approximate to 30 nm sized hexagonal-phase NaYF4:Yb,Er UCNPs. By utilizing Na0.52YbF3.52:Er@SrF2 UCNPs as multifunctional nanoplatforms, highly efficient in vitro and in vivo 915 nm light-triggered photodynamic therapies are realized for the first time, with dramatically diminished overheating yet similar therapeutic effects in comparison to those triggered by 980 nm light. Moreover, by virtue of the high transverse relaxivity (r(2)) and the strong X-ray attenuation ability of Yb3+ ions, these UCNPs also demonstrate good performances as contrast agents for high contrast magnetic resonance and X-ray computed tomography dual-modal imaging. Our research shows the great potential of the red emitting Na0.52YbF3.52:Er UCNPs for multimodal imaging-guided photodynamic therapy of tumors. |
| 关键词[WOS] | NEAR-INFRARED LIGHT ; DRUG-DELIVERY ; NANO-BIOPROBES ; UPCONVERTING NANOPARTICLES ; CANCER-THERAPY ; RED-EMISSION ; NANOCRYSTALS ; LUMINESCENCE ; PHOTOSENSITIZERS ; NAYF4YB3+,ER3+ |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383376300004 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4846]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米研究国际实验室_蔺洪振团队 |
| 推荐引用方式 GB/T 7714 | Huang, YA,Xiao, QB,Hu, HS,et al. 915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes[J]. SMALL,2016,12(31). |
| APA | Huang, YA.,Xiao, QB.,Hu, HS.,Zhang, KC.,Feng, YM.,...&Lin, HZ.(2016).915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes.SMALL,12(31). |
| MLA | Huang, YA,et al."915 nm Light-Triggered Photodynamic Therapy and MR/CT Dual-Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes".SMALL 12.31(2016). |
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