Effect of XingPiJieYu decoction on spatial learning and memory and cAMP-PKA-CREBBDNF pathway in rat model of depression through chronic unpredictable stress
文献类型:期刊论文
作者 | Wang, Chunye2; Guo, Jianyou1; Guo, Rongjuan2; Guo,Jianyou |
刊名 | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE |
出版日期 | 2017-01-24 |
卷号 | 17期号:0页码:1-12 |
通讯作者邮箱 | guojy@psych.ac.cn ; dfguorongjuan@163.com |
ISSN号 | 1472-6882 |
关键词 | Chinese herbs Depression Learning and memory Chronic unpredictable stress CAMP PKA CREB BDNF |
通讯作者 | Guo, Jianyou ; Guo, Rongjuan |
英文摘要 | Background: Depression is a mental disorder characterized by a pervasive low mood and loss of pleasure or interest in usual activities, and often results in cognitive dysfunction. The disturbance of cognitive processes associated with depression, especially the impairment of learning and memory, exacerbates illness and increases recurrence of depression. XingPiJieYu (XPJY) is one of the most widely clinical formulas of traditional Chinese medicine (TCM) and can improve the symptoms of depression, including learning and memory. However, its regulatory effects haven't been comprehensively studied so far. Recently, some animal tests have indicated that the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-cAMP response element-binding protein (CREB)brain derived neurotrophic factor (BDNF) signaling pathway in hippocampus is closely related to depression and the pathogenesis of cognitive function impairments. The present study was performed to investigate the effect and mechanism of XPJY on depression and learning and memory in animal model. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Integrative & Complementary Medicine |
研究领域[WOS] | Integrative & Complementary Medicine |
关键词[WOS] | LATE-LIFE DEPRESSION ; CHRONIC MILD STRESS ; ELEMENT-BINDING PROTEIN ; NEUROTROPHIC FACTOR ; PHOSPHODIESTERASE-4 INHIBITOR ; COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE ; MOOD DISORDERS ; CYCLIC-AMP ; HIPPOCAMPAL NEUROGENESIS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000392998500001 |
源URL | [http://ir.psych.ac.cn/handle/311026/21200] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Guo,Jianyou |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Beijing Univ Chinese Med, Dongfang Hosp, Beijing 100078, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Chunye,Guo, Jianyou,Guo, Rongjuan,et al. Effect of XingPiJieYu decoction on spatial learning and memory and cAMP-PKA-CREBBDNF pathway in rat model of depression through chronic unpredictable stress[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017,17(0):1-12. |
APA | Wang, Chunye,Guo, Jianyou,Guo, Rongjuan,&Guo,Jianyou.(2017).Effect of XingPiJieYu decoction on spatial learning and memory and cAMP-PKA-CREBBDNF pathway in rat model of depression through chronic unpredictable stress.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,17(0),1-12. |
MLA | Wang, Chunye,et al."Effect of XingPiJieYu decoction on spatial learning and memory and cAMP-PKA-CREBBDNF pathway in rat model of depression through chronic unpredictable stress".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 17.0(2017):1-12. |
入库方式: OAI收割
来源:心理研究所
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