Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran
文献类型：期刊论文
| 作者 | Ding, Wei-Yi1,2; Ai, Jun3; Wang, Xin-Long1; Qiu, Fayang G.4,5; Lv, Qing1; Fang, Ping1; Hou, Fan-Fan3; Yan, Yong-Ming1; Cheng, Yong-Xian1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:81页码:77887-77897 |
| 英文摘要 | Lingzhifuran A (1) and lingzhilactones D-F (2-4), four new phenolic meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. Their structures were identified by spectroscopic data. Chiral HPLC analysis indicates the racemic nature of 2-4. Chiral separation followed by X-ray diffraction analysis discloses the absolute configuration of (-)-2. Compounds 1 and 2 could selectively inhibit TGF-beta 1-induced Smad3 phosphorylation in rat renal tubular epithelial cells, representing novel scaffolds of selective Smad3 activation inhibitors. Total synthesis accompanied by in vivo rodent experiments reveals antifibrotic activities of 1 against kidney fibrosis. Finally, a plausible biosynthetic pathway for 1 was proposed. |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | RENAL INTERSTITIAL FIBROSIS ; OBSTRUCTIVE NEPHROPATHY ; URETERAL OBSTRUCTION ; BIOSYNTHESIS ; MECHANISMS ; COCHLEAR ; (+/-)-LINGZHIOL ; MEROTERPENOIDS ; DIBENZOFURANS ; CYCLIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000382482200085 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/33611]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100049, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res,Natl Clin Res Ctr, Guangzhou 510515, Guangdong, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Mol Engn, Guangzhou 510530, Guangdong, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Nat Prod Synth, Guangzhou 510530, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Wei-Yi,Ai, Jun,Wang, Xin-Long,et al. Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran[J]. RSC ADVANCES,2016,6(81):77887-77897. |
| APA | Ding, Wei-Yi.,Ai, Jun.,Wang, Xin-Long.,Qiu, Fayang G..,Lv, Qing.,...&Cheng, Yong-Xian.(2016).Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran.RSC ADVANCES,6(81),77887-77897. |
| MLA | Ding, Wei-Yi,et al."Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran".RSC ADVANCES 6.81(2016):77887-77897. |
入库方式： OAI收割
来源：昆明植物研究所
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