Lindenane sesquiterpenoid dimers from Chloranthus japonicus inhibit HIV-1 and HCV replication
文献类型：期刊论文
| 作者 | Yan, Haan1,6; Ba, Ming -Yu2,3; Li, Xu-Hong1,6; Guo, Jia-Mei2,3; Qin, Xu-Jie1,6 ; He, Li4; Zhang, Zhong-Quan5; Guo, Ying2,3; Liu, Hai-Yang1,6
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 115期号:1页码:64-68 |
| 关键词 | Chloranthus japonicus Chlorajaponilides F-H Anti-HIV-1 Anti-HCV |
| 英文摘要 | Phytochemical investigation on the whole plant of Chloranthus japonicus (Chloranthaceae) led to the isolation and identification of three new lindenane-type sesquiterpenoid dimers, chlorajaponilides F-H (1-3), along with seven known ones (4-10). Their chemical structures were established by extensive spectral evidence. Compounds 1 and 2 are both dimeric sesquiterpenoids featuring a rare hydroperoxy group at C-5. All compounds were tested for their activities on wild type HIV-1 replication and compounds 1, 2, 5, and 9 were effective with EC50 values from 3.08 to 17.16 mu M. All these four compounds showed the same inhibitory effects on the two NNRTI-resistant HIV strains as on wild-type HIV-1 with EC50 change folds from 0.61 to 1.6 mu M. Furthermore, compounds 1, 5, and 9 exhibited inhibitory activities on HCV replication with the similar potency as their activities on HIV-1. Our finding may provide a clue to address the problem of HIV-1 and HCV co-infection. (C) 2016 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | HEPATITIS-C VIRUS ; REVERSE-TRANSCRIPTASE ; INFECTION ; SPICATUS ; SYSTEM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000389113300011 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/33749]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China 3.Peking Union Med Coll, Beijing 100050, Peoples R China 4.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China 5.Chinese Acad Forestry, Res Inst Resource Insects, Kunming 650224, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Haan,Ba, Ming -Yu,Li, Xu-Hong,et al. Lindenane sesquiterpenoid dimers from Chloranthus japonicus inhibit HIV-1 and HCV replication[J]. FITOTERAPIA,2016,115(1):64-68. |
| APA | Yan, Haan.,Ba, Ming -Yu.,Li, Xu-Hong.,Guo, Jia-Mei.,Qin, Xu-Jie.,...&Liu, Hai-Yang.(2016).Lindenane sesquiterpenoid dimers from Chloranthus japonicus inhibit HIV-1 and HCV replication.FITOTERAPIA,115(1),64-68. |
| MLA | Yan, Haan,et al."Lindenane sesquiterpenoid dimers from Chloranthus japonicus inhibit HIV-1 and HCV replication".FITOTERAPIA 115.1(2016):64-68. |
入库方式： OAI收割
来源：昆明植物研究所
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