Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi
文献类型：期刊论文
| 作者 | Liu, Yu-Chen1,2; Su, Jia1; Wu, Xing-De1; Zhang, Zhi-Jun1,2; Fan, Min1,2 ; Zhu, Qin-Feng1,2; He, Juan1; Li, Xiao-Nian1; Peng, Li-Yan1; Cheng, Xiao1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 115期号:1页码:148-154 |
| 关键词 | Phlegmariurus henryi Lycopodium alkaloids Anti-AChE activity Cytotoxicity |
| 英文摘要 | A series of new Lycopodium alkaloids, namely 1-epi-malycorin A (1), 1-epi-17S-hydroxymalycorin A (2), 6 alpha-thydroxyphlegmariurine A (3), 2S,4R-dihydroxyfawcettimine (4), and 16-hydroxylycodine (5), together with 24 known ones, have been isolated from the club moss Phlegmariurus henryi. The structures of the new compounds were determined by extensive spectroscopic analysis, including 1D and 2D NMR, as well as X-ray crystallographic analysis. Among them, the absolute configurations of 1, 2, and 4 and the structure of 3 were confirmed on the basis of the single-crystal X-ray diffraction analysis. 1-Epi-17S-hydroxymalycorin A (2) was a unique C19N-type Lycopodium alkaloid consisting of a serratinine skeleton with 1,2-propanediol unit. 2S,4R-dihydroxyfawcettimine (4) was a 2,4-dihydroxy derivative of fawcettimine.16-Hydroxylycodine (5) was the oxidative product of lycodine with an unusual hydroxymethyl group at C-15. All new compounds were evaluated for in vitro acetylcholinesterase (AChE) inhibitory activity and cytotoxicity against four human cancer cell lines. (C) 2016 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | ACETYLCHOLINESTERASE INHIBITORY-ACTIVITY ; FAWCETTIMINE-RELATED ALKALOIDS ; LYCODINE-TYPE ALKALOIDS ; HUPERZIA-SERRATA ; CASUARINOIDES ; ANNOTINUM ; THUNB |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000389113300024 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/33756]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yu-Chen,Su, Jia,Wu, Xing-De,et al. Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi[J]. FITOTERAPIA,2016,115(1):148-154. |
| APA | Liu, Yu-Chen.,Su, Jia.,Wu, Xing-De.,Zhang, Zhi-Jun.,Fan, Min.,...&Zhao, Qin-Shi.(2016).Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi.FITOTERAPIA,115(1),148-154. |
| MLA | Liu, Yu-Chen,et al."Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi".FITOTERAPIA 115.1(2016):148-154. |
入库方式： OAI收割
来源：昆明植物研究所
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