中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging

文献类型:期刊论文

作者Chen, Junling1,4; Liu, Tianzhou2; Gao, Jing1; Gao, Lan3,4; Zhou, Lulu1,4; Cai, Mingjun1; Shi, Yan1; Xiong, Wenyong3; Jiang, Junguang1; Tong, Ti2
刊名ADVANCED SCIENCE
出版日期2016-12-01
卷号3期号:12页码:1600270
英文摘要Carbohydrate alterations on cell membranes are associated with various cancer processes, including tumorigenesis, malignant transformation, and tumor dissemination. However, variations in the distributions of cancer-associated carbohydrates are unclear at the molecular level. Herein, direct stochastic optical reconstruction microscopy is used to reveal that seven major types of carbohydrates tended to form obvious clusters on cancer cell membranes compared with normal cell membranes (both cultured and primary cells), and most types of carbohydrates present a similar distributed characteristic on various cancer cells (e.g., HeLa and Os-Rc-2 cells). Significantly, sialic acid is found to distribute in larger-sized clusters with a higher cluster coverage percentage on various cancer cells than normal cells. These findings on the aberrant distributions of cancer-associated carbohydrates can potentially serve as novel diagnostic and therapeutic targets, as well as making a contribution to clarify how abnormal glycosylations of membrane glycoconjugates participate in tumorigenesis and metastasis.
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]TUMOR PROGRESSION ; BINDING-SPECIFICITY ; MAACKIA-AMURENSIS ; LECTIN-BINDING ; O-GLYCANS ; GLYCOSYLATION ; SURFACE ; ADHESION ; SIALYLATION ; FIBRONECTIN
收录类别SCI
语种英语
WOS记录号WOS:000390399000015
源URL[http://ir.kib.ac.cn/handle/151853/33797]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
2.Jilin Univ, Hosp 2, Changchun 130022, Jilin, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Chen, Junling,Liu, Tianzhou,Gao, Jing,et al. Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging[J]. ADVANCED SCIENCE,2016,3(12):1600270.
APA Chen, Junling.,Liu, Tianzhou.,Gao, Jing.,Gao, Lan.,Zhou, Lulu.,...&Wang, Hongda.(2016).Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging.ADVANCED SCIENCE,3(12),1600270.
MLA Chen, Junling,et al."Variation in Carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging".ADVANCED SCIENCE 3.12(2016):1600270.

入库方式: OAI收割

来源:昆明植物研究所

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