(+/-)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum
文献类型：期刊论文
| 作者 | Li, Lei1,2; Li, Huan2,3,4; Peng, Xing-Rong1; Hou, Bo1,2; Yu, Mu-Yuan1,2 ; Dong, Jin-Run1,2; Li, Xiao-Nian1; Yang, Jian3,4; Qiu, Ming-Hua1,2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2016-12-02 |
| 卷号 | 18期号:23页码:6078-6081 |
| 英文摘要 | (+/-) Ganoapplanin (1), a pair of novel meroterpenoid enantiomers featuring an unprecedented dioxaspiro cyclic skeleton constructed from a 6/6/6/6 tetracyclic system and an unusual tricyclo-. [4.3.3.0(3',7')]dodecane motif, were isolated from Ganoderma applanatum. Its structure and absolute configurations were determined by spectroscopic analyses, X-ray crystallography, and ECD (electronic circular dichroism calculations). A plausible biogenetic pathway, involving a key Gomberg Bachmann reaction, was also proposed for (+/-)-1. Biological studies showed that (+/-)-1 and its enantiomers exhibited different inhibitory activities on T-type voltage-gated calcium channels. |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CALCIUM-CHANNEL INHIBITORS ; LANOSTANE TRITERPENOIDS ; COCHLEAR ; CULTURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000389396100028 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/33762]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Ion Channel Res & Drug Dev Ctr, Kunming 650223, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lei,Li, Huan,Peng, Xing-Rong,et al. (+/-)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum[J]. ORGANIC LETTERS,2016,18(23):6078-6081. |
| APA | Li, Lei.,Li, Huan.,Peng, Xing-Rong.,Hou, Bo.,Yu, Mu-Yuan.,...&Qiu, Ming-Hua.(2016).(+/-)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum.ORGANIC LETTERS,18(23),6078-6081. |
| MLA | Li, Lei,et al."(+/-)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum".ORGANIC LETTERS 18.23(2016):6078-6081. |
入库方式： OAI收割
来源：昆明植物研究所
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