Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis
文献类型：期刊论文
| 作者 | Zhang, Xingwang1,2 ; Li, Zhong1,2,3; Du, Lei1,2,3; Chlipala, George E.4,5,6; Lopez, Patricia C.4,5,6; Zhang, Wei1,2; Sherman, David H.4,5,6; Li, Shengying1,2
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| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2016-12-28 |
| 卷号 | 57期号:52页码:5919-5923 |
| 关键词 | Tirandamycin Natural product Tetramic acid Biosynthesis Streptomyces |
| 英文摘要 | Tirandamycin K (7), the first linear 7,13;9,13-diseco-tirandamycin derivative, was isolated from the tamI (encoding the TamI P450 monooxygenase) disruption mutant strain (Delta tamI) of marine Streptomyces sp. 307-9. Its chemical structure with relative and absolute configurations was elucidated by a combination of extensive spectroscopic analyses and biosynthetic inferences. Structural elucidation of this unusual compound provides new insights into tirandamycin biosynthesis. Moreover, examination of the biological activity of 7 confirms the essential function of the bicyclic ketal ring for antibiotic activities of tirandamycins. (C) 2016 Published by Elsevier Ltd. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | BACTERIAL RNA-POLYMERASE ; STREPTOMYCES SP 17944 ; GENE-CLUSTER ; ACID ; STREPTOLYDIGIN ; INHIBITOR ; METABOLITE ; GENERATION ; SYNTHASES ; ENZYMES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000390738700021 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/9200]  |
| 专题 | 青岛生物能源与过程研究所_酶工程团队 |
| 作者单位 | 1.Chinese Acad Sci, Shandong Prov Key Lab Synthet Biol, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Michigan, Inst Life Sci, Dept Med Chem, Ann Arbor, MI 48109 USA 5.Univ Michigan, Inst Life Sci, Dept Chem, Ann Arbor, MI 48109 USA 6.Univ Michigan, Inst Life Sci, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Xingwang,Li, Zhong,Du, Lei,et al. Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis[J]. TETRAHEDRON LETTERS,2016,57(52):5919-5923. |
| APA | Zhang, Xingwang.,Li, Zhong.,Du, Lei.,Chlipala, George E..,Lopez, Patricia C..,...&Li, Shengying.(2016).Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.TETRAHEDRON LETTERS,57(52),5919-5923. |
| MLA | Zhang, Xingwang,et al."Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis".TETRAHEDRON LETTERS 57.52(2016):5919-5923. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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