2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells
文献类型：期刊论文
| 作者 | Xu, Li; Chen, Yangsheng; Xie, Heidi Q. H.; Xu, Tuan; Fu, Hualing; Zhang, Songyan; Tsim, Karl W. K.; Bi, Cathy W. C.; Zhao, Bin |
| 刊名 | CHEMICO-BIOLOGICAL INTERACTIONS
 |
| 出版日期 | 2016-11-25 |
| 卷号 | 259期号:0页码:282-285 |
| 关键词 | AChE Acetylcholinesterase Dioxin 2,3,7,8-TCDD PC12 Neuronal differentiation NGF Nerve growth factor |
| 英文摘要 | PC12 is a well studied cell model for neuronal differentiation. AChE is also considered as a marker for neuronal differentiation. In this study, we detected the change of AChE activity during the NGF induced differentiation of PC 12 cells, and targeted on the ratio of the activity of AChE on the cell surface, and found that NGF mainly increased the intracellular AChE activity. Dioxin is a kind of persistent organic pollutants which have extreme impact on human health and widely distributed all over the world. Recently, AChE was reported as a target of the toxicity of dioxin. Here we investigated the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on AChE activity in the PC12 cells, and found that at the later stage of differentiation, TCDD could decrease the AChE activity. This down regulation might not related to transcriptional regulation. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| 收录类别 | SCI |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/35790]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xu, Li,Chen, Yangsheng,Xie, Heidi Q. H.,et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells[J]. CHEMICO-BIOLOGICAL INTERACTIONS,2016,259(0):282-285. |
| APA | Xu, Li.,Chen, Yangsheng.,Xie, Heidi Q. H..,Xu, Tuan.,Fu, Hualing.,...&Zhao, Bin.(2016).2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells.CHEMICO-BIOLOGICAL INTERACTIONS,259(0),282-285. |
| MLA | Xu, Li,et al."2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells".CHEMICO-BIOLOGICAL INTERACTIONS 259.0(2016):282-285. |
入库方式： OAI收割
来源：生态环境研究中心
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