Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation
文献类型：期刊论文
| 作者 | Hou, Jie; Wan, Bin; Yang, Yu; Ren, Xiao-Min; Guo, Liang-Hong; Liu, Jing-Fu |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2016-03 |
| 卷号 | 17期号:3页码:- |
| 关键词 | respiratory burst in vitro enzymatic system single-walled carbon nanotubes biodegradation |
| 英文摘要 | The biodegradation of carbon nanotubes (CNTs) may be one of major determinants of the toxic outcomes in exposed individuals. In this study, we employed a macrophage/monocyte model, Raw264.7, to investigate the feasibility of regulating the biodegradation of three types of single-walled carbon nanotubes (SWCNTs) (pristine, ox-, and OH-SWCNTs) by respiratory burst modulation. An artificial fluid mimicking the enzymatic reactions of respiratory burst was constituted to reveal the role of respiratory burst played in SWCNT biodegradation. The biodegradation of SWCNTs were characterized by Raman, ultraviolet-visible-near-infrared spectroscopy, and transmission electron microscopy. Our results showed significantly accelerated biodegradation of ox-SWCNTs and OH-SWCNTs in macrophages activated by phorbol myristate acetate (PMA), which could be prevented by N-acetyl-l-cysteine (NAC), whereas p-SWCNTs were resistant to biodegradation. Similar tendencies were observed by using the in vitro enzymatic system, and the degradation rates of these SWCNTs are in the order of OH-SWCNTs > ox-SWCNTs >> p-SWCNTs, suggesting a pivotal role of respiratory burst in accelerating the biodegradation of SWCNTs and that defect sites on SWCNTs might be a prerequisite for the biodegradation to occur. Our findings might provide invaluable clues on the development of intervention measurements for relieving the side effects of SWCNTs and would help to design safer SWCNT products with higher biodegradability and less toxicity. |
| 收录类别 | SCI |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/35808]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Hou, Jie,Wan, Bin,Yang, Yu,et al. Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(3):-. |
| APA | Hou, Jie,Wan, Bin,Yang, Yu,Ren, Xiao-Min,Guo, Liang-Hong,&Liu, Jing-Fu.(2016).Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(3),-. |
| MLA | Hou, Jie,et al."Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.3(2016):-. |
入库方式： OAI收割
来源：生态环境研究中心
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