Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis
文献类型：期刊论文
| 作者 | Fan, Rui-mei; Zhu, Ben-zhan; Huang, Chin-pao; Sheng, Zhi-guo; Mao, Li; Li, Ming-xin |
| 刊名 | ENVIRONMENTAL TOXICOLOGY
 |
| 出版日期 | 2016-12 |
| 卷号 | 31期号:12页码:1964-1973 |
| 关键词 | metam copper (II) zinc (II) synergistic toxicity apoptosis necrosis |
| 英文摘要 | Both metam sodium and copper/zinc-containing compounds are widely used as fungicides. They therefore may co-occur in the biosphere. Despite certain studies of individual toxicity for either metam or copper (II)/zinc (II), their synergistic toxicity has not been examined. In this paper, a remarkable synergistic toxicity was observed in HepG2 cells when metam and copper (II)/zinc (II) at non-toxic and sub-toxic levels were combined. Unexpectedly, cell death modes between metam/copper (II) and metam/zinc (II) were different: For metam/copper (II), apoptosis was evident from morphological characteristics including cytoplasm-chromatin condensation, phosphatidylserine (PS) exposure, SubG(0)/G(1) DNA fragmentation, mitochondrial membrane potential decrease, pro/anti-apoptotic protein activation, and cytochrome c release; for metam/zinc (II), necrosis was evident from organelle swelling and uncontrolled collapse. To our knowledge, this work first not only demonstrates the synergistic toxicities of metam and both copper (II)/zinc (II), but also verifies the different modes of apoptosis/necrosis between metam/copper (II) and metam/zinc (II). (C) 2015 Wiley Periodicals, Inc. |
| 收录类别 | SCI |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/35839]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Fan, Rui-mei,Zhu, Ben-zhan,Huang, Chin-pao,et al. Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis[J]. ENVIRONMENTAL TOXICOLOGY,2016,31(12):1964-1973. |
| APA | Fan, Rui-mei,Zhu, Ben-zhan,Huang, Chin-pao,Sheng, Zhi-guo,Mao, Li,&Li, Ming-xin.(2016).Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis.ENVIRONMENTAL TOXICOLOGY,31(12),1964-1973. |
| MLA | Fan, Rui-mei,et al."Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis".ENVIRONMENTAL TOXICOLOGY 31.12(2016):1964-1973. |
入库方式： OAI收割
来源：生态环境研究中心
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