Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines
文献类型：期刊论文
| 作者 | Liu, Lihong; Zhang, Yu ; Yun, Zhaojun; He, Bin; Jiang, Guibin
|
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2016-01 |
| 卷号 | 39期号:0页码:37-44 |
| 关键词 | Bioaccessibility Mercury Chinese patent medicine Simulated digestion extraction |
| 英文摘要 | Mercury (Hg), mainly in cinnabar species, has been used in medicine for thousands of years in China, and worldwide concern has been raised on its toxicity. In this work, the amount of bioaccessible mercury in 16 Chinese patent medicines (CPMs) was measured by using an in vitro simulated digestion system, consisting of simulated gastric and intestinal fluid, to investigate the bioavailability of mercury in CPMs and evaluate its potential risk to human health. Total mercury and mercury in the gastrointestinal extracts were measured by inductively coupled plasma mass spectrometry (ICP-MS). The levels of total Hg in 16 CPMs ranged from not detected to 11.89 mu g/g, with a mean value of 1.13 mu g/g, while the extractable Hg ranged from not detected to 4.37 mu g/g, with a mean value of 0.42 mu g/g. Mercury bioaccessibility varied significantly in the investigated CPMs, depending on the ingredient. Compared to the CPMs without cinnabar (2.5%-30.9%), the percentage of mercury in the gastrointestinal supernatants for CPMs with cinnabar was quite a bit lower (0.037%). By comparing with the Food and Agricultural Organization/World Health Organization Joint Expert Committee on Food Additives (FAO/WHO) safety guideline, the average daily intake dose (ADD) of Hg in the medicines was then calculated to access the risk of mercury to human health from taking CPMs. (C) 2015 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 收录类别 | SCI |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/35851]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Lihong,Zhang, Yu,Yun, Zhaojun,et al. Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2016,39(0):37-44. |
| APA | Liu, Lihong,Zhang, Yu,Yun, Zhaojun,He, Bin,&Jiang, Guibin.(2016).Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines.JOURNAL OF ENVIRONMENTAL SCIENCES,39(0),37-44. |
| MLA | Liu, Lihong,et al."Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines".JOURNAL OF ENVIRONMENTAL SCIENCES 39.0(2016):37-44. |
入库方式： OAI收割
来源：生态环境研究中心
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