Genotoxicity of quinolone antibiotics in chlorination disinfection treatment: formation and QSAR simulation
文献类型：期刊论文
| 作者 | Li, Min; Wei, Dongbin; Du, Yuguo |
| 刊名 | ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
 |
| 出版日期 | 2016-10 |
| 卷号 | 23期号:20页码:20637-20645 |
| 关键词 | Quinolone Chlorination Disinfection Genotoxicity QSAR CoMSIA |
| 英文摘要 | Lots of unexpected disinfection by-products were formed during the chlorination disinfection of contaminated water bodies, leading to a potential threat to human health and ecological safety. In this study, SOS/umu assay was used to trace the genotoxicity variation of 20 quinolone compounds during the chlorination disinfection. Furthermore, two- and three-dimensional quantitative structure-activity relationship models were developed based on the electronic and hydrophobic properties of the quinolones, which were used to quantify the impact of the different structural features of the compounds on their genotoxicity variation. The results revealed that quinolones bearing hydrophilic substituents with less H-bond donors and negative charge at the 1-position of the quinolone ring exhibited a positive correlation with genotoxicity elevation. More notably, the chlorination of quinolones in both ultrapure water and secondary effluent matrices provided comparable levels of genotoxicity, indicating that our research could potentially be used to evaluate the environmental risk of quinolone antibiotics in chlorination disinfection treatment. |
| 收录类别 | SCI |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/35862]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Min,Wei, Dongbin,Du, Yuguo. Genotoxicity of quinolone antibiotics in chlorination disinfection treatment: formation and QSAR simulation[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2016,23(20):20637-20645. |
| APA | Li, Min,Wei, Dongbin,&Du, Yuguo.(2016).Genotoxicity of quinolone antibiotics in chlorination disinfection treatment: formation and QSAR simulation.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,23(20),20637-20645. |
| MLA | Li, Min,et al."Genotoxicity of quinolone antibiotics in chlorination disinfection treatment: formation and QSAR simulation".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 23.20(2016):20637-20645. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。