Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
文献类型：期刊论文
| 作者 | Zhang, Yi; Wang, Yabin; Liu, Aijuan; Xu, Sherry Li; Zhao, Bin; Zhang, Yi; Zou, Hanfa; Wang, Wenyi; Zhu, Hao; Yan, Bing |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2016-02-09 |
| 卷号 | 26期号:6页码:841-850 |
| 关键词 | combinatorial chemistry CYP450 functionalized MWCNTs human liver microsome pharmacophores |
| 英文摘要 | The liver plays an important role in metabolizing foreign materials, such as drugs. The high accumulation of carbon nanotubes and other hydrophobic nanoparticles in the liver has raised concerns that nanoparticles may interfere with liver metabolic function. We report here that carbon nanotubes enter hepatic cells after intravenous introduction and interact with CYP enzymes, including CYP3A4. Surface chemical modifications alter the carbon nanotubes' interactions with CYP450 enzymes in human liver microsomes. They enhance, inhibit, or have no effect on the enzymatic function of CYP3A4. Using a cheminformatics analysis, certain chemical structures are identified on the surface of the carbon nanotubes that induce an enzyme inhibitory effect or prevent disruption of CYP3A4 enzymes. |
| 收录类别 | SCI |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/35897]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Yi,Wang, Yabin,Liu, Aijuan,et al. Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver[J]. ADVANCED FUNCTIONAL MATERIALS,2016,26(6):841-850. |
| APA | Zhang, Yi.,Wang, Yabin.,Liu, Aijuan.,Xu, Sherry Li.,Zhao, Bin.,...&Yan, Bing.(2016).Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver.ADVANCED FUNCTIONAL MATERIALS,26(6),841-850. |
| MLA | Zhang, Yi,et al."Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver".ADVANCED FUNCTIONAL MATERIALS 26.6(2016):841-850. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。