Oxidative stress and immunotoxicity induced by graphene oxide in zebrafish
文献类型：期刊论文
| 作者 | Chen, Minjie; Yin, Junfa; Liang, Yong; Yuan, Shaopeng; Wang, Fengbang; Song, Maoyong; Wang, Hailin |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2016-05 |
| 卷号 | 174期号:0页码:54-60 |
| 关键词 | Graphene oxide Acute toxicity Zebrafish Oxidative stress Immunotoxicity |
| 英文摘要 | Graphene oxide (GO) has been extensively explored as a promising nanomaterial for applications in biology because of its unique properties. Therefore, systematic investigation of GO toxicity is essential to determine its fate in the environment and potential adverse effects. In this study, acute toxicity, oxidative stress and immunotoxicity of GO were investigated in zebrafish. No obvious acute toxicity was observed when zebrafish were exposed to 1, 5, 10 or 50 mg/L GO for 14 days. However, a number of cellular alterations were detected by histological analysis of the liver and intestine, including vacuolation, loose arrangement of cells, histolysis and disintegration of cell boundaries. As evidence for oxidative stress, malondialdehyde levels and superoxide dismutase and catalase activities were increased and glutathione content was decreased in the liver after treatment with GO. GO treatment induced an immune response in zebrafish, as demonstrated by increased expression of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in the spleen. Our findings demonstrated that GO administration in an aquatic system can cause oxidative stress and immune toxicity in adult zebrafish. To our knowledge, this is the first report of immune toxicity of GO in zebrafish. (C) 2016 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/35919]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Minjie,Yin, Junfa,Liang, Yong,et al. Oxidative stress and immunotoxicity induced by graphene oxide in zebrafish[J]. AQUATIC TOXICOLOGY,2016,174(0):54-60. |
| APA | Chen, Minjie.,Yin, Junfa.,Liang, Yong.,Yuan, Shaopeng.,Wang, Fengbang.,...&Wang, Hailin.(2016).Oxidative stress and immunotoxicity induced by graphene oxide in zebrafish.AQUATIC TOXICOLOGY,174(0),54-60. |
| MLA | Chen, Minjie,et al."Oxidative stress and immunotoxicity induced by graphene oxide in zebrafish".AQUATIC TOXICOLOGY 174.0(2016):54-60. |
入库方式： OAI收割
来源：生态环境研究中心
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