High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke
文献类型：期刊论文
| 作者 | Wang, Jing1; Zhang, Hua1; Ni, Dalong2; Fan, Wenpei2; Qu, Jianxun1; Liu, Yanyan2; Jin, Yingying1; Cui, Zhaowen2; Xu, Tianyong1; Wu, Yue1 |
| 刊名 | SMALL
 |
| 出版日期 | 2016-07-13 |
| 卷号 | 12期号:26页码:3591-3600 |
| 英文摘要 | Multimodal magnetic resonance (MR) imaging, including MR angiography (MRA) and MR perfusion (MRP), plays a critical role in the diagnosis and surveillance of acute ischemic stroke. However, these techniques are hindered by the low T-1 relaxivity, short circulation time, and high leakage rate from vessels of clinical Magnevist. To address these problems, nontoxic polyethylene glycol (PEG)ylated upconversion nanoprobes (PEG-UCNPs) are synthesized and first adopted for excellent MRA and MRP imaging, featuring high diagnostic sensitivity toward acute ischemic stroke in high-resolution imaging. The investigations show that the agent possesses superior advantages over clinical Magnevist, such as much higher relaxivity, longer circulation time, and lower leakage rate, which guarantee much better imaging efficiency. Remarkably, an extremely small dosage (5 mg Gd kg(-1)) of PEG-UCNPs provides high-resolution MRA imaging with the vascular system delineated much clearer than the Magnevist with clinical dosage as high as 108 mg Gd kg(-1). On the other hand, the long circulation time of PEG-UCNPs enables the surveillance of the progression of ischemic stroke using MRA or MRP. Once translated, these PEG-UCNPs are expected to be a promising candidate for substituting the clinical Magnevist in MRA and MRP, which will significantly lengthen the imaging time window and improve the overall diagnostic efficiency. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | IN-VIVO ; COMPUTED-TOMOGRAPHY ; CONTRAST AGENT ; DRUG-DELIVERY ; NANOPARTICLES ; NANOCRYSTALS ; THERAPY ; LUMINESCENT ; ANGIOGRAPHY ; TIME |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383374600013 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/22831]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Zhang, Hua,Ni, Dalong,et al. High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke[J]. SMALL,2016,12(26):3591-3600. |
| APA | Wang, Jing.,Zhang, Hua.,Ni, Dalong.,Fan, Wenpei.,Qu, Jianxun.,...&Yao, Zhenwei.(2016).High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke.SMALL,12(26),3591-3600. |
| MLA | Wang, Jing,et al."High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke".SMALL 12.26(2016):3591-3600. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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