Synergistic retention strategy of RGD active targeting and radiofrequency-enhanced permeability for intensified RF & chemotherapy synergistic tumor treatment
文献类型：期刊论文
| 作者 | Zhang, Kun1,2; Li, Pei1,2; He, Yaping1,2; Bo, Xiaowan1; Li, Xiaolong1; Li, Dandan1; Chen, Hangrong3; Xu, Huixiong1,2 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 99页码:34-46 |
| 关键词 | Synergistic retention RGD active targeting Radiofrequency (RF)-enhanced permeability RF ablation Chemotherapy RF-responsive drug delivery |
| 英文摘要 | Despite gaining increasing attention, chelation of multiple active targeting ligands greatly increase the formation probability of protein corona, disabling active targeting. To overcome it, a synergistic retention strategy of RGD-mediated active targeting and radiofrequency (RF) electromagnetic field-enhanced permeability has been proposed here. It is validated that such a special synergistic retention strategy can promote more poly lactic-co-glycolic acid (PLGA)-based capsules encapsulating camptothecin (CPT) and solid DL-menthol (DLM) to enter and retain in tumor in vitro and in vivo upon exposure to RF irradiation, receiving an above 8 fold enhancement in HeLa retention. Moreover, the PLGA-based capsules can respond RF field to trigger the entrapped DLM to generate solid-liquid-gas (SLG) tri-phase transformation for enhancing RF ablation and CPT release. Therefore, depending on the enhanced RF ablation and released CPT and the validated synergistic retention effect, the inhibitory outcome for tumor growth has gained an over 10-fold improvement, realizing RF ablation & chemotherapy synergistic treatment against HeLa solid tumor, which indicates a significant promise in clinical RF ablation. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | LOADED PLGA NANOPARTICLES ; SOLID LIPID NANOPARTICLES ; DRUG-DELIVERY ; FOCUSED ULTRASOUND ; PROTEIN CORONA ; CAMPTOTHECIN ; LIPOSOME ; ABLATION ; THERAPY ; STABILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000378670100004 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/22942]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Med Ultrasound, 301 Yan Chang Zhong Rd, Shanghai 200072, Peoples R China 2.Tongji Univ, Sch Med, Ultrasound Res & Educ Inst, 301 Yan Hang Zhong Rd, Shanghai 200072, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Kun,Li, Pei,He, Yaping,et al. Synergistic retention strategy of RGD active targeting and radiofrequency-enhanced permeability for intensified RF & chemotherapy synergistic tumor treatment[J]. BIOMATERIALS,2016,99:34-46. |
| APA | Zhang, Kun.,Li, Pei.,He, Yaping.,Bo, Xiaowan.,Li, Xiaolong.,...&Xu, Huixiong.(2016).Synergistic retention strategy of RGD active targeting and radiofrequency-enhanced permeability for intensified RF & chemotherapy synergistic tumor treatment.BIOMATERIALS,99,34-46. |
| MLA | Zhang, Kun,et al."Synergistic retention strategy of RGD active targeting and radiofrequency-enhanced permeability for intensified RF & chemotherapy synergistic tumor treatment".BIOMATERIALS 99(2016):34-46. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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