A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo-Synergistic Cancer Therapy
文献类型：期刊论文
| 作者 | Zhang, Nan1,2; Cai, Xiaojun3; Gao, Wei1,2; Wang, Ronghui1,2; Xu, Chunyan1,2; Yao, Yuanzhi1,2; Hao, Lan1,2; Sheng, Danli1,2; Chen, Hangrong3; Wang, Zhigang1,2 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:3页码:404-417 |
| 关键词 | Hollow mesoporous Prussian blue Phase transformation Photoacoustic imaging High-intensity focused ultrasound Theranostics |
| 英文摘要 | High-intensity focused ultrasound (HIFU) is deemed to be a promising noninvasive therapeutic modality for cancers as well as non-neoplastic diseases. However, the accuracy of the technique in the diagnosis and treatment of tumors remains unsatisfactory. HIFU, when combined with multifunctional synergistic agents (SAs), has the potential to be of greater diagnostic and therapeutic efficacy. Here we describe a smart and multifunctional hollow mesoporous Prussian blue (HMPBs) theranostic nanoplatform, the hollow structure of which is capable of encapsulating doxorubicin (DOX) and perfluorohexane (HMPBs-DOX/PFH). In vitro and in vivo studies validated that HMPBs-DOX/PFH can be used as an amplifiable dual-mode imaging contrast agent, which can simultaneously enhance ultrasound (US) and photoacoustic (PA) imaging for guiding and monitoring tumor therapy. When exposed to HIFU, this versatile HMPBs-DOX/PFH agent could increase the cavitation effect and use lower HIFU intensity to achieve coagulative necrosis. Furthermore, it significantly accelerated the release of DOX thereby enhancing chemotherapeutic efficacy and avoiding systemic side effects of the drug. Such a novel theranostic nanoplatform is expected to integrate dual-mode guided imaging with greater therapeutic efficacy and fewer side effects and is very promising for the noninvasive synergistic tumor therapy. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | INTENSITY FOCUSED ULTRASOUND ; PRUSSIAN BLUE NANOPARTICLES ; CONTRAST AGENT ; DRUG-DELIVERY ; BREAST-CANCER ; SOLID TUMORS ; HIFU ; ABLATION ; VAPORIZATION ; FEASIBILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377797200009 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/22973]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China 2.Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Nan,Cai, Xiaojun,Gao, Wei,et al. A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo-Synergistic Cancer Therapy[J]. THERANOSTICS,2016,6(3):404-417. |
| APA | Zhang, Nan.,Cai, Xiaojun.,Gao, Wei.,Wang, Ronghui.,Xu, Chunyan.,...&Zheng, Yuanyi.(2016).A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo-Synergistic Cancer Therapy.THERANOSTICS,6(3),404-417. |
| MLA | Zhang, Nan,et al."A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo-Synergistic Cancer Therapy".THERANOSTICS 6.3(2016):404-417. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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