Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T-1-MRI contrast agents and drug delivery carriers
文献类型：期刊论文
| 作者 | Li, Xiaowei1; Zhao, Wenru1; Liu, Xiaohang2; Chen, Kaiqiang1; Zhu, Shaojia3; Shi, Ping3; Chen, Yu4; Shi, Jianlin1,4 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2016-01-15 |
| 卷号 | 30页码:378-387 |
| 关键词 | Manganese silicate Stimuli-responsive T-1-weighted MRI Contrast agents Drug delivery |
| 英文摘要 | A novel kind of monodisperse mesoporous manganese silicate coated silica nanoparticle (MMSSN) as a highly efficient T-1-weighted MRI contrast agent (CA) and drug carrier for cancer diagnosis and chemotherapy has been constructed by a modified "SiO2 sacrifice and in situ silicate growth" approach under a relatively low hydrothermal temperature and alkali-free condition. The mesoporous manganese silicate shell provides a large specific surface area and abundant exposed Mn paramagnetic centers to water molecules, which endows the MMSSN5 with extraordinarily high longitudinal relaxivity. Meanwhile, the MMSSNs presented an efficient pH/redox-responsive T-1-MRI feature based on the significant enhancement of relaxation rate (r(1)) stimulated by mild acidic environment or reducing agent (GSH) both in vitro and in vivo. Furthermore, the mesoporous structure and negatively charged pore surface of the manganese silicate shell enable the MMSSN5 to attain anti-cancer drug (DOX) storage and a pH-responsive release, which is suitable for on-demand drug release for the chemotherapy of tumors. Therefore, the mesoporous manganese silicate-based nanomaterial is a promising candidate as T-1-MRI CAs and anticancer-drug delivery carriers for the theranostics of tumor in an intelligent and on-demand manner. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | SUPERPARAMAGNETIC IRON-OXIDE ; NEPHROGENIC SYSTEMIC FIBROSIS ; MAGNETIC-RESONANCE ; IN-VIVO ; ENHANCED MRI ; PH ; GADOLINIUM ; RELEASE ; PLATFORM ; FUNCTIONALIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000368563600034 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23273]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China 2.Fudan Univ, Shanghai Canc Ctr, Dept Radiol, Shanghai 200032, Peoples R China 3.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaowei,Zhao, Wenru,Liu, Xiaohang,et al. Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T-1-MRI contrast agents and drug delivery carriers[J]. ACTA BIOMATERIALIA,2016,30:378-387. |
| APA | Li, Xiaowei.,Zhao, Wenru.,Liu, Xiaohang.,Chen, Kaiqiang.,Zhu, Shaojia.,...&Shi, Jianlin.(2016).Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T-1-MRI contrast agents and drug delivery carriers.ACTA BIOMATERIALIA,30,378-387. |
| MLA | Li, Xiaowei,et al."Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T-1-MRI contrast agents and drug delivery carriers".ACTA BIOMATERIALIA 30(2016):378-387. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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