A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication
文献类型：期刊论文
| 作者 | Gao, Wei1,2; Zheng, Yuanyi1,2; Wang, Ronghui1,2; Chen, Hangrong3; Cai, Xiaojun3; Lu, Guangming4; Chu, Lei1,2; Xu, Chunyan1,2; Zhang, Nan1,2; Wang, Zhigang1,2 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2016 |
| 卷号 | 29页码:298-306 |
| 关键词 | Magnetic hyperthermia Phase transformation Chemotherapy Poly lactic-co-glycolic acid |
| 英文摘要 | Magnetic hyperthermia ablation is a new and minimally invasive modality for localized tumor removal. However, an inadequate ablation dosage can leave a residual tumor or cause a variety of complications. In addition, commonly used magnetic nanoparticles can easily escape from the tumor tissue, which present potential safety problems. In this study, a smart phase transitional and injectable implant based on biocompatible poly lactic-co-glycolic acid (PLGA) implant incorporating magnetic material (Fe powder) and anti-cancer drug (doxorubicin (DOX)) was developed. The magnetic-induced hyperthermia and release efficiency of DOX were evaluated in vitro. Drug release can be controlled under external alternating current magnetic field (AMF). The results of the in vivo tumor therapeutic efficacy showed that when exposed to external AMF, this smart injectable DOX/PLGA-Fe implant could converse magnetic energy into heat and accelerate the release of DOX, which leads to increasing the temperature to achieve tumor coagulative necrosis and accelerating the release of DOX to enhance residual tumor apoptosis. Furthermore, there was no leakage of magnetic material, as demonstrated using real-time ultrasound (US) and computerized tomography (CT) imaging, realizing the guidance and monitoring of tumor therapy. In conclusion, this smart phase transitional and injectable implant DOX/PLGA-Fe has the ability to improve the efficiency of this newly developed minimally invasive magnetic ablation of tumor treatment technique, and will provide a new avenue of developing minimally invasive synergistic tumor therapy. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | IRON-OXIDE NANOPARTICLES ; LOCAL MICROWAVE HYPERTHERMIA ; IN-VIVO ; FLUID HYPERTHERMIA ; DRUG-DELIVERY ; CHEMOTHERAPY TREATMENT ; THERMO-CHEMOTHERAPY ; CANCER ; CARCINOMA ; VITRO |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367490000029 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23293]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China 2.Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Beijing 100864, Peoples R China 4.Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing 210000, Jiangsu, Peoples R China 5.Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Wei,Zheng, Yuanyi,Wang, Ronghui,et al. A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication[J]. ACTA BIOMATERIALIA,2016,29:298-306. |
| APA | Gao, Wei.,Zheng, Yuanyi.,Wang, Ronghui.,Chen, Hangrong.,Cai, Xiaojun.,...&Song, Jinlin.(2016).A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication.ACTA BIOMATERIALIA,29,298-306. |
| MLA | Gao, Wei,et al."A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication".ACTA BIOMATERIALIA 29(2016):298-306. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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