Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics
文献类型：期刊论文
| 作者 | Zhou, Yang1,2; Wang, Ronghui3; Teng, Zhaogang4; Wang, Zhigang3; Hu, Bing1; Kolios, Michael5; Chen, Hangrong6; Zhang, Nan3; Wang, Yanjie5; Li, Pan3 |
| 刊名 | NPG ASIA MATERIALS
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 8 |
| 英文摘要 | The development of efficient strategies for in vivo stimuli-responsive cancer treatment and personalized biomedicine is a great challenge. To overcome the critical issues and limitations of traditional protocols using acoustic droplet vaporization and optical droplet vaporization in stimuli-responsive tumor treatment, we herein report a new strategy, magnetic droplet vaporization (MDV), based on nanobiotechnology, for efficient magnetic field-responsive cancer theranostics. Perfluorohexane (PFH)-encapsulated superparamagnetic hollow iron oxide nanoparticles with a high magnetic-thermal energy transfer capability quickly respond to an external alternating current (a.c.) magnetic field to produce thermal energy and raise the temperature of the surrounding tumor tissue. The encapsulated PFH, with a desirable boiling point of similar to 56 degrees C, can be vaporized to enhance the performance of ultrasound imaging of tumors, as systematically demonstrated both in vitro and in vivo. The magnetic-thermal energy transfer further ablated and removed tumors in mice tumor xenograft models. This unique MDV principle with high versatility and performance is expected to broaden the biomedical applications of nanotechnology and promote clinical translations of intelligent diagnostic and therapeutic modalities, especially for battling cancer. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Multidisciplinary |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | INTENSITY FOCUSED ULTRASOUND ; CONTRAST AGENTS ; DRUG-DELIVERY ; ABLATION ; THERAPY ; NANOCAPSULES ; CHEMOTHERAPY ; PLATFORM ; TUMORS ; ULTRASONOGRAPHY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000391939200003 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23380]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Inst Ultrasound Med, Affiliated Shanghai Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Third Peoples Hosp Chengdu, Chengdu, Peoples R China 3.Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China 4.Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, 305 Zhongshan Dong Rd, Nanjing 210002, Jiangsu, Peoples R China 5.Ryerson Univ, Dept Phys, Toronto, ON, Canada 6.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yang,Wang, Ronghui,Teng, Zhaogang,et al. Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics[J]. NPG ASIA MATERIALS,2016,8. |
| APA | Zhou, Yang.,Wang, Ronghui.,Teng, Zhaogang.,Wang, Zhigang.,Hu, Bing.,...&Zheng, Yuanyi.(2016).Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics.NPG ASIA MATERIALS,8. |
| MLA | Zhou, Yang,et al."Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics".NPG ASIA MATERIALS 8(2016). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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