Electrospinning of PELA/PPY Fibrous Conduits: Promoting Peripheral Nerve Regeneration in Rats by Self-Originated Electrical Stimulation
文献类型：期刊论文
| 作者 | Zhou, Zi-Fei1,2; Zhang, Fan1; Wang, Jian-Guang1; Chen, Quan-Chi1; Yang, Wei-Zhi1; He, Ning1; Jiang, Ying-Ying3; Chen, Feng3; Liu, Jun-Jian1 |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 2期号:9页码:1572-1581 |
| 关键词 | polypyrrole nerve regeneration tissue engineering electrospinning fibrous conduit |
| 英文摘要 | Peripheral nerve injuries represent a great challenge for surgeons. The conductive neural scaffold has experienced increasing interest because of its good biocompatibility and similar electrical properties as compared to those of a normal nerve. Herein, nerve conduits made from poly(D,L-lactide)-co-poly(ethylene glycol) and polypyrrole (20%, 30%, and 50%) (PELA-PPY) were prepared by electrospinning, and used in regeneration of peripheral nerve defects. The results of an in vitro experiment indicated a high biocompatibility for the as-prepared materials, supporting the attachment and proliferation of a rat pheochromocytoma PC-12 cell. Furthermore, the PELA-PPY nerve conduit implanted in the sciatic nerve defects (10 mm) of the Spraguee-Dawley rats for 12 weeks showed similar results with the autograft, while it demonstrated a better outcome than the PELA nerve conduit in electrophysiological examination, sciatic function index, total amount of regenerated myelinated nerve fibers, axon diameter, myelin thickness, and several immunohistochemistry indices (S-100, laminin, neurofilament, bromodeoxyuridine, and glial fibrillary acidic portein). We supposed that the bioactivity is mainly generated by the PPY in composite nanofibers which could transmit self-originated electrical stimulation between cells. Due to the facile preparation and excellent in vivo performance, the PPY-PELA nerve conduit is promising for use as a bioengineered biomaterial for peripheral nerve regeneration. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | EXTRACELLULAR-MATRIX ; FUNCTIONAL RECOVERY ; IN-VITRO ; CELL ; POLYPYRROLE ; GROWTH ; NANOFIBERS ; SCAFFOLDS ; POLYMERS ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383220000016 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/22852]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | 1.Tongji Univ, Shanghai Peoples Hosp 10, Dept Orthoped Surg, Shanghai 200072, Peoples R China 2.Tongji Univ, Shanghai East Hosp, Dept Orthoped Surg, Shanghai 200072, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Zi-Fei,Zhang, Fan,Wang, Jian-Guang,et al. Electrospinning of PELA/PPY Fibrous Conduits: Promoting Peripheral Nerve Regeneration in Rats by Self-Originated Electrical Stimulation[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2016,2(9):1572-1581. |
| APA | Zhou, Zi-Fei.,Zhang, Fan.,Wang, Jian-Guang.,Chen, Quan-Chi.,Yang, Wei-Zhi.,...&Liu, Jun-Jian.(2016).Electrospinning of PELA/PPY Fibrous Conduits: Promoting Peripheral Nerve Regeneration in Rats by Self-Originated Electrical Stimulation.ACS BIOMATERIALS SCIENCE & ENGINEERING,2(9),1572-1581. |
| MLA | Zhou, Zi-Fei,et al."Electrospinning of PELA/PPY Fibrous Conduits: Promoting Peripheral Nerve Regeneration in Rats by Self-Originated Electrical Stimulation".ACS BIOMATERIALS SCIENCE & ENGINEERING 2.9(2016):1572-1581. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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