Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery
文献类型：期刊论文
| 作者 | Ding, Guan-Jun; Zhu, Ying-Jie; Cheng, Guo-Feng; Ruan, Yin-Jie; Qi, Chao; Lu, Bing-Qiang; Chen, Feng; Wu, Jin |
| 刊名 | CURRENT NANOSCIENCE
 |
| 出版日期 | 2016 |
| 卷号 | 12期号:1页码:70-78 |
| 关键词 | Amorphous materials calcium phosphate casein drug delivery nanocomposite nanostructures. |
| 英文摘要 | Porous microspheres of casein/amorphous calcium phosphate nanocomposite are prepared using casein sodium salt, CaCl2, Na2HPO4 center dot 12H(2)O and NaH2PO4 center dot 2H(2)O in aqueous solution at room temperature. The effects of experimental parameters such as solution pH, casein sodium salt and ageing time on the product are investigated. Porous microspheres of casein/amorphous calcium phosphate nanocomposite are characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric (TG) analysis, and Brunauer-Emmett-Teller (BET) specific surface area and pore size distribution. The as-prepared porous microspheres of casein/amorphous calcium phosphate nanocomposite are favorable for drug loading and release using ibuprofen (IBU), docetaxel (Dtxl) and vitamin B5 (B5) as typical drugs, and show low cytotoxicity in the cytotoxicity test. Thus, porous microspheres of casein/amorphous calcium phosphate nanocomposite have promising applications in various biomedical fields such as drug delivery. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | ASSISTED HYDROTHERMAL SYNTHESIS ; CASEIN PHOSPHOPEPTIDES ; HYDROXYAPATITE ; PROTEIN ; SYSTEMS ; FLUTAMIDE ; MICELLES ; RELEASE ; NUTRACEUTICALS ; NANOPARTICLES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000372112600009 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23154]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Guan-Jun,Zhu, Ying-Jie,Cheng, Guo-Feng,et al. Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery[J]. CURRENT NANOSCIENCE,2016,12(1):70-78. |
| APA | Ding, Guan-Jun.,Zhu, Ying-Jie.,Cheng, Guo-Feng.,Ruan, Yin-Jie.,Qi, Chao.,...&Wu, Jin.(2016).Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery.CURRENT NANOSCIENCE,12(1),70-78. |
| MLA | Ding, Guan-Jun,et al."Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery".CURRENT NANOSCIENCE 12.1(2016):70-78. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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