Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting
文献类型：期刊论文
| 作者 | Huang, Hai1; Lan, Ping-Heng1; Zhang, Yong-Quan1; Li, Xiao-Kang1; Zhang, Xing2; Yuan, Chao-Fan1; Zheng, Xue-Bin3; Guo, Zheng1 |
| 刊名 | SURFACE & COATINGS TECHNOLOGY
 |
| 出版日期 | 2015-12-15 |
| 卷号 | 283页码:80-88 |
| 关键词 | Porous titanium Electron beam melting Bone ingrowth Hydroxyapatite Osteointegration Surface treatment |
| 英文摘要 | Porous titanium with high strength and a low elastic modulus has received attention as an excellent orthopedic implant; however, the fabrication and biological performance of porous implant both need to be improved. A porous Ti6Al4V implant (11) was prepared using the electron beam melting method, and some samples underwent surface modification with a hydroxyapatite coating (HA-TI) by plasma-spraying. After characterization of their surfaces, the TI and HA-TI materials were implanted into distal femur bone defects of sheep, and bone formation and osteointegration were evaluated at 2 and 4 months post-implantation. A micro computed tomography analysis indicated that the porous Ti6Al4V implant with interconnected pores had a high porosity similar to 69 +/- 5% and large pore size similar to 514 +/- 35 mu m. Scanning electron microscopy, energy dispersive spectrometry, and X-ray diffraction analyses revealed that the HA coating was successfully deposited on the exterior surface of the implants; the elemental composition of the internal surface of the HA-TI material included calcium and phosphorus, as well as titanium and aluminum. Confocal laser scanning microscopy revealed that the surface roughness of the HA-TI group was significantly higher than that of the TI group. Micro computed tomography and histological analyses indicated that the bone formation of the HA-TI group was superior to that of the TI group at both 2 and 4 months post-implantation. In the HA-TI group, the new bone contacted the coating of the implant directly, and no fibrous tissue or gaps were observed at the bone-implant interface. This study demonstrates that hydroxyapatite coating of porous Ti6Al4V implants by plasma-spraying is suitable to improve the bone formation and osteointegration capabilities. In addition, the results demonstrate that HA-coated porous Ti6Al4V implants generated by electron beam melting have excellent prospects in orthopedic applications. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology ; Physical Sciences |
| 类目[WOS] | Materials Science, Coatings & Films ; Physics, Applied |
| 研究领域[WOS] | Materials Science ; Physics |
| 关键词[WOS] | MECHANICAL-PROPERTIES ; TITANIUM IMPLANTS ; ORTHOPEDIC APPLICATIONS ; BIOMEDICAL APPLICATIONS ; TI-6AL-4V STRUCTURES ; BIOACTIVE TITANIUM ; TISSUE INGROWTH ; BONE-FORMATION ; SCAFFOLDS ; POROSITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000368557300010 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23269]  |
| 专题 | 上海硅酸盐研究所_特种无机涂层重点实验室_期刊论文 |
| 作者单位 | 1.Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China 3.Chinese Acad Sci, Key Lab Inorgan Coating Mat, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Hai,Lan, Ping-Heng,Zhang, Yong-Quan,et al. Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting[J]. SURFACE & COATINGS TECHNOLOGY,2015,283:80-88. |
| APA | Huang, Hai.,Lan, Ping-Heng.,Zhang, Yong-Quan.,Li, Xiao-Kang.,Zhang, Xing.,...&Guo, Zheng.(2015).Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting.SURFACE & COATINGS TECHNOLOGY,283,80-88. |
| MLA | Huang, Hai,et al."Surface characterization and in vivo performance of plasma-sprayed hydroxyapatite-coated porous Ti6Al4V implants generated by electron beam melting".SURFACE & COATINGS TECHNOLOGY 283(2015):80-88. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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