Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative: Modeling and optimization through response surface methodology
文献类型：期刊论文
| 作者 | Wang, J; Liu, Q; Rong, LY; Yang, H; Jiao, FP; Chen, XQ |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2016 |
| 卷号 | 1467页码:490-496 |
| 关键词 | Aqueous two-phase system beta-CD derivative Enantioselective extraction Response surface methodology Inclusion complexation |
| ISSN号 | 0021-9673 |
| 通讯作者 | Chen, XQ (reprint author), Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China. |
| 英文摘要 | A novel aqueous two-phase system (ATPS) composed beta-cyclodextrin (beta-CD) derivative and acetone was developed for enantioselective extraction of racemic phenylsuccinic acid (PSA). Binodal curves, tie-lines, and critical points for the investigated ATPS were determined and the experimental tie-lines data were successfully correlated by Othmer-Tobias, Bancroft, and Setschenow-type equations. ATPS containing sulfobutyl ether-beta-CD (SBE-beta-CD) exhibited better enantioselectivity than that using carboxymethyl-beta-CD (CM-beta-CD). To optimize enantioselective partitioning conditions of PSA in acetone/SBE-beta-CD ATPS, three factors (PSA concentration, pH, and equilibrium temperature) were analyzed by using central composite design in response surface methodology. The calculated equilibrium constants of inclusion complexation are 1638.64 M-1 for SBE-beta-CD-(R)-PSA and 835.84 M-1 for SBE-beta-CD-(S)-PSA, respectively. Under the optimized conditions, the separation factor of 3.14 and high enrichment efficiency (E-R = 98.06%, E-S =99.25%) were simultaneously achieved in a single step. (C) 2016 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385323800048 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/26494]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, J,Liu, Q,Rong, LY,et al. Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative: Modeling and optimization through response surface methodology[J]. JOURNAL OF CHROMATOGRAPHY A,2016,1467:490-496. |
| APA | Wang, J,Liu, Q,Rong, LY,Yang, H,Jiao, FP,&Chen, XQ.(2016).Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative: Modeling and optimization through response surface methodology.JOURNAL OF CHROMATOGRAPHY A,1467,490-496. |
| MLA | Wang, J,et al."Enantioselective extraction extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and beta-cyclodextrin derivative: Modeling and optimization through response surface methodology".JOURNAL OF CHROMATOGRAPHY A 1467(2016):490-496. |
入库方式： OAI收割
来源：上海应用物理研究所
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