High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles
文献类型：期刊论文
| 作者 | Ma, JF; Li, YL; Yu, BZ |
| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 16期号:7页码:7210-7214 |
| 关键词 | Carbon Nanotubes Gene Delivery Polyethylenimine 293T Cells |
| ISSN号 | 1533-4880 |
| 通讯作者 | Yu, BZ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Dept Molten Salt Chem & Engn, Shanghai 201800, Peoples R China. |
| 英文摘要 | High molecular weight PEI (600 K) modified multiwalled carbon nanotubes (HMWPEI-MWCNTs) were studied in 293T cells as safe and efficient gene delivery vehicles. The HMWPEI-MWCNTs exhibited low cytotoxicity, and had enough ability to condense DNA and obviously enhance gene transfer activity. The concentration of HMWPEI-MWCNTs to 100 mu g/mL showed less effect on the 60% of cell viability, while the cell viability of HMWPEI was around 20% at the same concentration. The transfection efficiency of HMWPEI-MWCNTs was around 1.8 times, and much higher than those of naked DNA under an optimal nitrogen/phosphate (N/P) ratio of 10:1. The study demonstrates the possibility of developing the novel safe and efficient gene delivery systems by adopting low toxic and biocompatible nanocomposite. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000387100400087 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/26527]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Ma, JF,Li, YL,Yu, BZ. High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(7):7210-7214. |
| APA | Ma, JF,Li, YL,&Yu, BZ.(2016).High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(7),7210-7214. |
| MLA | Ma, JF,et al."High Molecular Weight Polyethylenimine-Functionalized Multiwalled Carbon Nanotubes as Efficient Gene Delivery Vehicles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.7(2016):7210-7214. |
入库方式： OAI收割
来源：上海应用物理研究所
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