The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs
文献类型：期刊论文
| 作者 | Feng, YZ; Wang, BC; Chu, XX; Wang, YZ; Zhu, LC |
| 刊名 | MINI-REVIEWS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 16期号:10页码:846-850 |
| 关键词 | C-H activation detecting sensitivity human multi-trans membrane protein native conformation small drugs Virion-chip |
| ISSN号 | 1389-5575 |
| 通讯作者 | Wang, BC (reprint author), Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Shazheng St 174, Chongqing 400044, Peoples R China. |
| 英文摘要 | How to construct protein chips and chemically labeling drug molecules without disrupting structures for HTS is still a challenging area. There are two main obstacles, one is that human multitrans membrane receptors, which are major drug targets, exhibit distinct motifs, and fold structures, and they will collapse unfold without membrane support in vitro; another one is that there still lack effective chemical labeling method for small drugs for detection. Therefore, how to acquire high detecting sensitivity for small molecules and to immobilize membrane protein receptors in native conformation with uniform direction on the chip, need to be solved for drug HTS. This paper reviews drug HTS trends in recent years, proposed a new virion-chip model and a feasible C-H activation method for CY-5 labeling drugs. It is expected to provide a good platform for future drug HTS. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380946500008 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/26653]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Feng, YZ,Wang, BC,Chu, XX,et al. The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2016,16(10):846-850. |
| APA | Feng, YZ,Wang, BC,Chu, XX,Wang, YZ,&Zhu, LC.(2016).The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs.MINI-REVIEWS IN MEDICINAL CHEMISTRY,16(10),846-850. |
| MLA | Feng, YZ,et al."The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs".MINI-REVIEWS IN MEDICINAL CHEMISTRY 16.10(2016):846-850. |
入库方式： OAI收割
来源：上海应用物理研究所
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