Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy
文献类型：期刊论文
| 作者 | Shao, Leihou1,3; Zhang, Ruirui2; Lu, Jianqing1,3; Zhao, Caiyan1,3; Deng, Xiongwei1,3; Wu, Yan1,3 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-01-18 |
| 卷号 | 9期号:2页码:1226-1236 |
| 关键词 | polydopamine mesoporous silica reduced graphene oxide drug delivery chemo-photothermal therapy |
| ISSN号 | 1944-8244 |
| 英文摘要 | The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monotherapy. This work presents a novel nanoplatform which could load chemotherapy drugs with high efficiency and be used as light-mediated photothermal cancer therapy agent. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | OVERCOME DRUG-RESISTANCE ; IN-VIVO ; CANCER-THERAPY ; COMBINATION THERAPY ; SURFACE-CHEMISTRY ; NANO-GRAPHENE ; NANOPARTICLES ; DELIVERY ; NANOMATERIALS ; DOXORUBICIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000392458300009 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21898]  |
| 专题 | 过程工程研究所_湿法冶金清洁生产技术国家工程实验室 |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Ctr Excellence Nanosci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing Key Lab Ion Liquids Clean Proc, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Leihou,Zhang, Ruirui,Lu, Jianqing,et al. Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(2):1226-1236. |
| APA | Shao, Leihou,Zhang, Ruirui,Lu, Jianqing,Zhao, Caiyan,Deng, Xiongwei,&Wu, Yan.(2017).Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,9(2),1226-1236. |
| MLA | Shao, Leihou,et al."Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 9.2(2017):1226-1236. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。