Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery
文献类型：期刊论文
| 作者 | Li, Guo Liang1,3; Hu, Jinglei2,6; Wang, Hongqiang4,5; Pilz-Allen, Christine3; Wang, Junpeng1; Qi, Tao1; Moehwald, Helmuth3; Shchukin, Dmitry G.4 |
| 刊名 | POLYMER
 |
| 出版日期 | 2017-01-27 |
| 卷号 | 109页码:332-338 |
| ISSN号 | 0032-3861 |
| 关键词 | Anisotropic nanocontainer Silica/Polymer hybrids Controlled release |
| 英文摘要 | We report on amphiphilic diblock copolymer-decorated anisotropic silica nanotubes with well-defined dual functions of shape and surface properties in one nanocontainer. Amphiphilic poly(lactic acid)block-poly(ethylene glycol) (PLA-b-PEG) diblock copolymers are covalently grafted to the surface of mesoporous silica nanotubes via silane chemistry and esterification. The released percentage of probe molecules from the resultant silica-g-(PLA-b-PEG) hybrid nanocontainer is around 40% over a release time of 48 h, in contrast to 90% from bare silica nanotubes prior to surface modification. The diblock copolymer-decorated anisotropic nanocontainers with large aspect ratio lead to enhanced viability of NIH 3T3 fibroblast cells. A theoretical model based on the free energy cost for cell membranes to encapsulate nanocontainers is utilized to understand the cytotoxicity. This work demonstrates that the release dynamics of the active molecules and the interaction of hybrid nanocontainers with cell membranes can be regulated by the synergistic effect of nanocontainer shape and surface properties. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Polymer Science |
| 研究领域[WOS] | Polymer Science |
| 关键词[WOS] | DRUG-DELIVERY ; BLOCK-COPOLYMERS ; CLICK-CHEMISTRY ; NANOPARTICLES ; OXIDE ; THERAPY ; CORE ; NANOCONTAINERS ; NANOSTRUCTURES ; NANOREACTORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000393532300034 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21928]  |
| 专题 | 过程工程研究所_湿法冶金清洁生产技术国家工程实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Engn Lab Hydrometallurg Cleaner Prod Technol, Beijing 100190, Peoples R China 2.Nanjing Univ, Kuang Yarning Honors Sch, Nanjing 210093, Jiangsu, Peoples R China 3.Max Planck Inst Colloids & Interfaces, Wissensch Pk Golm,Muhlenberg 1, D-14476 Potsdam, Germany 4.Univ Liverpool, Dept Chem, Stephenson Inst Renewable Energy, Liverpool L69 7ZD, Merseyside, England 5.Northwestern Polytech Univ, Sch Mat Sci & Engn, Ctr Nano Energy Mat, State Key Lab Solidificat Proc, Xian 710072, Peoples R China 6.Nanjing Univ, Shenzhen Inst Res, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Guo Liang,Hu, Jinglei,Wang, Hongqiang,et al. Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery[J]. POLYMER,2017,109:332-338. |
| APA | Li, Guo Liang.,Hu, Jinglei.,Wang, Hongqiang.,Pilz-Allen, Christine.,Wang, Junpeng.,...&Shchukin, Dmitry G..(2017).Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery.POLYMER,109,332-338. |
| MLA | Li, Guo Liang,et al."Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery".POLYMER 109(2017):332-338. |
入库方式： OAI收割
来源：过程工程研究所
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