Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey
文献类型：期刊论文
| 作者 | Li MH1; Li SY1,2; Xia HJ1,2; Wang L1,2; Wang YY1,2; Zhang GH1; Zheng YT[*]1 |
| 刊名 | VIROLOGICA SINICA
 |
| 出版日期 | 2007 |
| 卷号 | 22期号:6页码:509-516 |
| 关键词 | AIDS SIV SIVmac239 HIV Primate animal model Chinese rhesus monkey |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 中文摘要 | In the present research, two Chinese rhesus monkeys were inoculated intravenously with 5000 TCID50 of SIVmac239. The changes in the numbers of CD4+ T lymphocyte in peripheral blood, plasma viral loads, proviral DNA and humoral antibodies against virus were periodically monitored during 121 days. At the early stage of infection, proviral DNA had been detected in PBMCs, and infectious SIVmac239 virus had been isolated from PBMCs. At the same period, the numbers of CD4+ T lymphocytes were significantly decreased, and maintained at low level during the 121-day period of infection. Plasma viral loads reached the peak at week 2 post-inoculation and kept at a steady state subsequently. Moreover, antibodies against viral proteins were detected from plasma. All the results showed that the two Chinese rhesus monkeys had been infected with SIVmac239 successfully. This animal model can be applied for further AIDS researches. |
| 收录类别 | 其他 |
| 资助信息 | Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences. |
| 语种 | 中文 |
| 公开日期 | 2010-11-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6416]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Chin 2.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Li MH,Li SY,Xia HJ,et al. Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey[J]. VIROLOGICA SINICA,2007,22(6):509-516. |
| APA | Li MH.,Li SY.,Xia HJ.,Wang L.,Wang YY.,...&Zheng YT[*].(2007).Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey.VIROLOGICA SINICA,22(6),509-516. |
| MLA | Li MH,et al."Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey".VIROLOGICA SINICA 22.6(2007):509-516. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。