Relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews (Tupaia belangeri chinensis)
文献类型：期刊论文
| 作者 | Wu X[*]1; Chang Q1; Zhang Y1; Zou X2; Chen L3; Zhang L1; Lv L1; Liang B[*]1 |
| 刊名 | Journal of Animal Physiology and Animal Nutrition
 |
| 出版日期 | 2013 |
| 卷号 | 97期号:6页码:1179-1188 |
| 关键词 | age relationship body weight fasting blood glucose concentration sex tree shrew (Tupaia belangeri chinensis) |
| 通讯作者 | liangb@mail.kiz.ac.cn ; wuxiaoyun@ mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The tree shrew (Tupaia belangeri chinensis) is a squirrel-like lower primate or a close relative of primates, commonly used as an animal model in biomedical research. Despite more than three decades of usage in research, the clear relationships between body weight, fasting blood glucose concentration, sex and age among tree shrews remain unclear. Based on an investigation of 992 tree shrews (454 males and 538 females) aged between 4months and 4years old, we found that male tree shrews have significantly higher body weight and fasting blood glucose concentration than female tree shrews (p<0.001). The concentration of fasting blood glucose slightly increased with body weight in males (r=0.152, p<0.001). Meanwhile, in females, the body weight, concentration of fasting blood glucose and waist circumference positively increased with age (p<0.001). Additionally, 17 tree shrews with Lee index [body weight (g)*0.33*1000/body length (cm)] above 290 had significantly higher body weight, waist circumference and glycated haemoglobin A1c (HbA1c) than non-obese tree shrews with a Lee index score below 290 (p<0.001). Interestingly, 6 of 992 tree shrews (three males and three females, 2-4years old) displayed impaired plasma triglycerides, HbA1c, low-density lipoprotein and oral glucose tolerance test, suggestive of the early symptoms of metabolic syndrome. This study provides the first clear relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews, further improving our understanding of this relationship in metabolic syndrome (MetS). Given the similarity of tree shrews to humans and non-human primates, this finding supports their potential use as an animal model in the research of MetS. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Innovative Program of the Chi- nese Academy of Sciences (KSCX2-EW-R-12 and KSCX2-EW-J-23), the National 863 Project of China (2012AA021801, 2012AA022402), as well as the National Natural Science Foundation of China (U1202223andY301261041)andtheWestLightFoun- dationoftheChineseAcademyofSciencestoXYW. |
| 语种 | 英语 |
| WOS记录号 | WOS:000327251800021 |
| 公开日期 | 2013-12-30 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7752]  |
| 专题 | 昆明动物研究所_脂类代谢与疾病 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Provinces, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Department of Life Science and Biotechnology, Kunming University, Kunming, China 3.Laboratory Zoology Department, Kunming Medical University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Wu X[*],Chang Q,Zhang Y,et al. Relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews (Tupaia belangeri chinensis)[J]. Journal of Animal Physiology and Animal Nutrition,2013,97(6):1179-1188. |
| APA | Wu X[*].,Chang Q.,Zhang Y.,Zou X.,Chen L.,...&Liang B[*].(2013).Relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews (Tupaia belangeri chinensis).Journal of Animal Physiology and Animal Nutrition,97(6),1179-1188. |
| MLA | Wu X[*],et al."Relationships between body weight, fasting blood glucose concentration, sex and age in tree shrews (Tupaia belangeri chinensis)".Journal of Animal Physiology and Animal Nutrition 97.6(2013):1179-1188. |
入库方式： OAI收割
来源：昆明动物研究所
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