A clinical and mechanistic study of topical borneol-induced analgesia
文献类型：期刊论文
| 作者 | Wang S[*]1,2; Zhang D3; Su DY2; Song HL4; Xu ZC1,2; Cui JM1,5; Zhou M1,6; Yang J[*]1,7; Hu JS1,2; Xiao JR[*]3 |
| 刊名 | EMBO Molecular Medicine
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:Published online |
| 关键词 | TRPM8 borneol pain topical analgesic traditional Chinese medicine |
| 通讯作者 | wangshu@mail.kiz.ac.cn or shu_wang@outlook.com |
| 英文摘要 | Bingpian is a time-honored herb in traditional Chinese medicine (TCM). It is an almost pure chemical with a chemical composition of (+)-borneol and has been historically used as a topical analgesic for millennia. However, the clinical efficacy of topical borneol lacks stringent evidence-based clinical studies and verifiable scientific mechanism. We examined the analgesic efficacy of topical borneol in a randomized, double-blind, placebo-controlled clinical study involving 122 patients with postoperative pain. Topical application of borneol led to significantly greater pain relief than placebo did. Using mouse models of pain, we identified the TRPM8 channel as a molecular target of borneol and showed that topical borneol-induced analgesia was almost exclusively mediated by TRPM8, and involved a downstream glutamatergic mechanism in the spinal cord. Investigation of the actions of topical borneol and menthol revealed mechanistic differences between borneol- and menthol-induced analgesia and indicated that borneol exhibits advantages over menthol as a topical analgesic. Our work demonstrates that borneol, which is currently approved by the US FDA to be used only as a flavoring substance or adjuvant in food, is an effective topical pain reliever in humans and reveals a key part of the molecular mechanism underlying its analgesic effect. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (81302865), Yunnan Applied Basic Research Projects (2013FB074), Youth Innovation Promotion Association of the Chinese Academy of Sciences, West Light Foundation of the Chinese Academy of Sciences, and Key Research Program of the Chinese Academy of Sciences (KJZD-EW-L03) to Shu Wang; grants from the Top Talents Program of Yunnan Province (2011HA012), National Basic Research Program of China (2014CB910301), High-level Over- seas Talents of Yunnan Province, Yunnan Major Science and Technology Project (2015ZJ002), and the National Natural Science Foundation of China (NSFC) (31370821) to Jian Yang; grants from the High-level Overseas Talents of Yunnan Province and the National Basic Research Program of China (2014CB910301) to Ming Zhou; and a grant from the High-level Overseas Talents of Yunnan Province to Jianmin Cui. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11027]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_化学生物学中心 昆明动物研究所_离子通道药物研发中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.Department of Orthopedic Oncology, Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China 4.Department of Preventive Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China 5.Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA 6.Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA 7.Department of Biological Sciences, Columbia University, New York, NY, USA |
| 推荐引用方式 GB/T 7714 | Wang S[*],Zhang D,Su DY,et al. A clinical and mechanistic study of topical borneol-induced analgesia[J]. EMBO Molecular Medicine,2017,**(**):Published online. |
| APA | Wang S[*].,Zhang D.,Su DY.,Song HL.,Xu ZC.,...&Xu W.(2017).A clinical and mechanistic study of topical borneol-induced analgesia.EMBO Molecular Medicine,**(**),Published online. |
| MLA | Wang S[*],et al."A clinical and mechanistic study of topical borneol-induced analgesia".EMBO Molecular Medicine **.**(2017):Published online. |
入库方式： OAI收割
来源：昆明动物研究所
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