In vivo antimalarial activity of synthetic hepcidin against Plasmodium berghei in mice
文献类型：期刊论文
| 作者 | Fang YQ1; Shen CB2,3; Lai R[*]1; Yan XW[*]1; Luan N1; Yao HM1; Long CB1 |
| 刊名 | Chinese Journal of Natural Medicines
 |
| 出版日期 | 2017 |
| 卷号 | 15期号:3页码:161-167 |
| 关键词 | Hepcidin Malaria Cytokine Inflammation Iron |
| 通讯作者 | rlai72@njau.edu.cn ; yanxw@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | The present study was designed to investigate the antimalarial activity of synthetic hepcidin and its effect on cytokine secretion in mice infected with Plasmodium berghei. The mice were infected with P. berghei intravenously and treated with hepcidin according to 4-day suppression test and Rane's test. The serum levels of interleukins (IL-1β, IL-2, IL-6, IL-10, IL-12p70, and IL-17A), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in the experimental mice were determined using a cytometric bead array (CBA) kit. The survival rate of the infected mice was also registered. Additionally, the serum iron, alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin (BIL) were detected to evaluate liver functions. Hepcidin exerted direct anti-malarial function in vivo and increased survival rate in a dose-dependent manner. In addition, the secretion of T helper cell type 1 (Th1), Th2, and Th17 cytokines, TNF-α, and IFN-γ were inhibited by hepcidin. In conclusion, our results demonstrated that synthetic hepcidin exerts in vivo antimalarial activity and possesses anti-inflammatory function, which provides a basis for future design of new derivatives with ideal anti-malarial activity. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by the grants from China National Natural Science Foundation of Young Scientists (No. 31201717), Special Foundation for Young Scientists of Jiangsu Province (No. BK2012365), Jiangsu Province Science and Technology Support Project (No. BE2012748). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11029]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_动物毒素室 |
| 作者单位 | 1.College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; 3.University of Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Fang YQ,Shen CB,Lai R[*],et al. In vivo antimalarial activity of synthetic hepcidin against Plasmodium berghei in mice[J]. Chinese Journal of Natural Medicines,2017,15(3):161-167. |
| APA | Fang YQ.,Shen CB.,Lai R[*].,Yan XW[*].,Luan N.,...&Long CB.(2017).In vivo antimalarial activity of synthetic hepcidin against Plasmodium berghei in mice.Chinese Journal of Natural Medicines,15(3),161-167. |
| MLA | Fang YQ,et al."In vivo antimalarial activity of synthetic hepcidin against Plasmodium berghei in mice".Chinese Journal of Natural Medicines 15.3(2017):161-167. |
入库方式： OAI收割
来源：昆明动物研究所
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