Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive–compulsive symptoms
文献类型：期刊论文
| 作者 | Cai J1; Zhang W2; Chen J3; Yu SY4; Fang Y[*]3; Zheng C[*]1,2; Yi ZH1; Lu WH1; Wu ZG3 |
| 刊名 | Psychopharmacology
 |
| 出版日期 | 2013 |
| 卷号 | 230期号:X页码:49–55 |
| 关键词 | Clozapine Obsessivecompulsivesymptom Glutamatetransmission Gene–geneinteraction Schizophrenia |
| 其他题名 | zhangchen645@gmail.com; yirufang@yahoo.com.cn |
| 合作状况 | 其它 |
| 英文摘要 | Clinical observations indicate that atypical antipsychotics, especially clozapine, induce obsessive-compulsive (OC) symptoms in schizophrenia patients. Recent data from neuroimaging and clinical trials suggest a role for altered glutamate neurotransmission in the etiology of OC disorder (OCD), and SLC1A1, GRIN2B, and GRIK2 have all been reported to regulate glutamate transmission and affect OCD pathophysiology. This study aimed to determine whether SLC1A1, GRIN2B, and GRIK2 are associated with clozapine-induced OC symptoms. A total of 250 clinically stable schizophrenia patients receiving clozapine treatment were recruited. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to evaluate the severity of OC symptoms. Based on their Y-BOCS scores, 250 patients were divided into the OC and non-OC groups (patients with or without OC symptoms, respectively). Additionally, three reported OCD susceptibility polymorphisms, SLC1A1 (rs2228622), GRIN2B (rs890), and GRIK2 (rs1556995), were genotyped. Trends of association with OC symptoms were observed in rs2228622A and rs890T alleles. SLC1A1 and GRIN2B interaction was found in the significant two-locus gene-gene interaction model (p = 0.0021), using the multifactor dimensionality reduction method. Further analysis showed a significant interaction between SLC1A1 and GRIN2B on the Y-BOCS score (F (6, 137) = 7.650, p < 0.001), and individuals with AA/TT genotypes had a significantly higher mean Y-BOCS score than those with other genotypes, except AG/TT. These results suggest that SLC1A1, GRIN2B, and interactions between the two may potentially confer a susceptibility to OC symptoms in schizophrenia patients receiving clozapine. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (81000581), Shanghai Science & Technology Development Foundation (12140904200), and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH2011-873). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11063]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_分子免疫药理学 昆明动物研究所_重大疾病机理的遗传学 |
| 作者单位 | 1.Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, People’s Republic of China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People’s Republic of China 3.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, People’s Republic of China 4.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Cai J,Zhang W,Chen J,et al. Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive–compulsive symptoms[J]. Psychopharmacology,2013,230(X):49–55. |
| APA | Cai J.,Zhang W.,Chen J.,Yu SY.,Fang Y[*].,...&Wu ZG.(2013).Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive–compulsive symptoms.Psychopharmacology,230(X),49–55. |
| MLA | Cai J,et al."Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive–compulsive symptoms".Psychopharmacology 230.X(2013):49–55. |
入库方式： OAI收割
来源：昆明动物研究所
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