Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy
文献类型：期刊论文
| 作者 | Yang ZZ[*]1; Su ZY[*]1,3; Li XJ1; Han L1; Li DQ1; Xia JF1; Zhang Y1; Yang YH1; DeWitt JP3; Jin CG7 |
| 刊名 | EBioMedicine
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:In press |
| 关键词 | Fluvastatin Autophagy Lung adenocarcinoma bone metastasis Statins p53 |
| 通讯作者 | yangzuozhang@163.com ; suzhenyi999@163.com |
| 英文摘要 | Bone is one of the most preferred sites of metastasis in lung cancer. Currently, bisphosphonates and denosumab are major agents for controlling tumor-associated skeletal-related events (SREs). However, both bisphosphonates and denosumab significantly increase the risk for jaw osteonecrosis. Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and the most frequently prescribed cholesterol-lowering agents, have been reported to inhibit tumor progression and induce autophagy in cancer cells. However, the effects of statin and role of autophagy by statin on bone metastasis are unknown. In this study, we report that fluvastatin effectively prevented lung adenocarcinoma bone metastasis in a nude mouse model. We further reveal that fluvastatin-induced anti-bone metastatic property was largely dependent on its ability to induce autophagy in lung adenocarcinoma cells. Atg5 or Atg7 deletion, or 3-methyadenine (3-MA) or Bafilomycin A1 (Baf A1) treatment prevented the fluvastatin-induced suppression of bone metastasis. Furthermore, we reveal that fluvastatin stimulation increased the nuclear p53 expression, and fluvastatin-induced autophagy and anti-bone metastatic activity were mostly dependent on p53. |
| 资助信息 | This research was supported, in part, by grants from the National Natural Science Foundation of China (Nos. 81460440, 31670798, 81260322, 81372322 and 81560471), the National Key Research and Development Program of China, Stem Cell and Translational Research (2016YFA0100900), the Joint Special Funds for the Department of Sci- ence and Technology of Yunnan Province-Kunming Medical University (No. 2014FB059), the Scientific Research Projects from Internal Re- search Institutions of Medical and Health Units in Yunnan Province (Nos. 2014NS013, 2014NS014, 2014NS015 and 2014NS016), Founda- tion of the Yunnan Provincial Innovative Team of Bone and Soft Tissue Tumor(No.2015HC026),FoundationoftheYoungandMiddle-agedAc- ademic and Technical Leaders of Yunnan Province (No. 2014HB034) andDoctorScientificResearchStartupFundsoftheThirdAffiliatedHos- pital of Kunming Medical University (No. BSJJ201406). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11237]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_肿瘤信号转导 |
| 作者单位 | 1.BoneandSoftTissueTumorsResearchCenterofYunnanProvince,DepartmentofOrthopaedics,TheThirdAffiliatedHospitalofKunmingMedicalUniversity(TumorHospitalofYunnanProvince), Kunming, Yunnan 650118, China 2.Department of Biochemistry and Molecular Biology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China 3.Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA 4.Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China 5.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 6.Cancer Institute, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China 7.Department of Radiology, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China |
| 推荐引用方式 GB/T 7714 | Yang ZZ[*],Su ZY[*],Li XJ,et al. Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy[J]. EBioMedicine,2017,**(**):In press. |
| APA | Yang ZZ[*].,Su ZY[*].,Li XJ.,Han L.,Li DQ.,...&Chen YB.(2017).Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy.EBioMedicine,**(**),In press. |
| MLA | Yang ZZ[*],et al."Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy".EBioMedicine **.**(2017):In press. |
入库方式： OAI收割
来源：昆明动物研究所
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