p53 codon 72 polymorphism and endometriosis: a meta-analysi
文献类型：期刊论文
| 作者 | Jia ST1,2; Xu L3; Yu HJ4; Yang HJ3; Luo Y[*]1; Tang WR[*]1,4; Chan Y1; Wu XM1; Yang SH1 |
| 刊名 | ARCHIVES OF GYNECOLOGY AND OBSTETRICS
 |
| 出版日期 | 2012 |
| 卷号 | 285期号:X页码:1657-1661 |
| 关键词 | p53 Meta-analysis Endometriosis |
| 通讯作者 | luoyingabc@yahoo.com ; twr@sina.com |
| 英文摘要 | p53 tumour suppressor gene Arg72Pro polymorphism has been associated with endometriosis. However, the current available data were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and endometriosis. Electronic screening of PubMed library was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Six published studies, including 749 endometriosis and 857 controls were identified. The overall results suggested that the variant genotypes were not associated with the endometriosis risk (Pro/Pro + Arg/Pro vs. Arg/Arg: OR = 1.552, 95% CI 0.916-2.632, = 0.103). In the stratified analysis, individuals carried the Pro allele in a dominant model had increased risk of endometriosis (OR = 2.595, 95% CI 1.005-6.702, = 0.049) in Asian subjects. The symmetric funnel plot, the Egger's test ( = 0.602), and the Begg's test ( = 0.167) were all suggestive of the lack of publication bias. However, the association was not significant between this polymorphism and endometriosis in Caucasian (OR = 1.005, 95% CI 0.755-1.337, = 0.972). This meta-analysis suggests that p53 codon 72 Pro/Pro + Arg/Pro genotypes are associated with increased risk of endometriosis in Asian. To validate the association between p53 codon 72 polymorphism and endometriosis, further studies with larger participants worldwide are needed. |
| 收录类别 | SCI |
| 资助信息 | This work was financially supported by the National Science Foundation of China (No. 30960152), the Nature Science Foundation of Yunnan Province (No. 2008C043M), and the Fund of State Key Laboratory of Genetics Resources and Evolution (No. GREKF10-07). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11060]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_基因起源组 |
| 作者单位 | 1.Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming 650500, Yunnan, China 2.Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming 650500, Yunnan, Chin 3.Department of Gynaecology, First Affiliated Hospital of Kunming Medical College, Kunming, China 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Jia ST,Xu L,Yu HJ,et al. p53 codon 72 polymorphism and endometriosis: a meta-analysi[J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS,2012,285(X):1657-1661. |
| APA | Jia ST.,Xu L.,Yu HJ.,Yang HJ.,Luo Y[*].,...&Yang SH.(2012).p53 codon 72 polymorphism and endometriosis: a meta-analysi.ARCHIVES OF GYNECOLOGY AND OBSTETRICS,285(X),1657-1661. |
| MLA | Jia ST,et al."p53 codon 72 polymorphism and endometriosis: a meta-analysi".ARCHIVES OF GYNECOLOGY AND OBSTETRICS 285.X(2012):1657-1661. |
入库方式： OAI收割
来源：昆明动物研究所
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