Lack of association between p53 codon 72 polymorphism and endometrial cancer: A meta-analysis
文献类型：期刊论文
| 作者 | Tang WR1,2,3; He XG1,2; Chan Y1,2; Luo Y[*]1,2 |
| 刊名 | Cancer Epidemiology
 |
| 出版日期 | 2012 |
| 卷号 | 36期号:X页码:e153–e157 |
| 关键词 | p53 Meta-analysis Endometrial cancer |
| 通讯作者 | twr@sina.com ; richer168@163.com ; cyhilda@163.com ; luoyingabc@yahoo.com |
| 英文摘要 | Background: It has been suggested that the p53 tumor suppressor gene Arg72Pro polymorphism is associated with endometrial cancer. However, results have been inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and endometrial cancer. Methods: An electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and the association was assessed by pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results: Nine published studies, including 829 endometrial cancer cases and 1387 controls, were identified. The overall results suggested that the variant genotypes were not associated with the endometrial cancer risk in all genetic models (additive model: OR 1.027, 95% CI 0.893-1.18, P = 0.71; recessive model: OR 1.099, 95% CI 0.802-1.507, P = 0.556; dominant model: OR 1.013, 95% CI 0.842-1.219 P = 0.89). Similarly, the results were negative in subgroup analyses for ethnicity (Caucasian, Asian). Conclusion: This meta-analysis suggests that p53 codon 72 polymorphism is not associated with increased risk of endometrial cancer, especially in Caucasians and Asians. To validate the association between this polymorphism and endometrial cancer, further studies with larger numbers of participants worldwide are needed. (C) 2012 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 资助信息 | This work was financially supported by the National Science Foundation of China (No. 30960152), the Nature Science Foundation of Yunnan Province (No. 2008C043M), and the Fund of State Key Laboratory of Genetics Resources and Evolution (No. GREKF10-07). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11061]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_基因起源组 |
| 作者单位 | 1.Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, 650500 Yunnan, China 2.Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, 650500 Yunnan, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Tang WR,He XG,Chan Y,et al. Lack of association between p53 codon 72 polymorphism and endometrial cancer: A meta-analysis[J]. Cancer Epidemiology,2012,36(X):e153–e157. |
| APA | Tang WR,He XG,Chan Y,&Luo Y[*].(2012).Lack of association between p53 codon 72 polymorphism and endometrial cancer: A meta-analysis.Cancer Epidemiology,36(X),e153–e157. |
| MLA | Tang WR,et al."Lack of association between p53 codon 72 polymorphism and endometrial cancer: A meta-analysis".Cancer Epidemiology 36.X(2012):e153–e157. |
入库方式： OAI收割
来源：昆明动物研究所
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