The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain
文献类型：期刊论文
| 作者 | Zhao XD1; D'Arca D1; Lim WK2,3; Brahmachary M3; Carro MS1; Ludwig T1,4; Cardo CC4; Guillemot F5; Aldape K6; Califano A2,3 |
| 刊名 | DEVELOPMENTAL CELL
 |
| 出版日期 | 2009 |
| 卷号 | 17期号:2页码:210-221 |
| 通讯作者 | ai2102@columbia.edu ; al2179@columbia.edu |
| 英文摘要 | Self-renewal and proliferation of neural stem cells and the decision to initiate neurogenesis are crucial events directing brain development. Here we show that the ubiquitin ligase Huwe1 operates upstream of the N-Myc-DLL3-Notch pathway to control neural stem cell activity and promote neurogenesis. Conditional inactivation of the Huwe1 gene in the mouse brain caused neonatal lethality associated with disorganization of the laminar patterning of the cortex. These defects stemmed from severe impairment of neurogenesis associated with uncontrolled expansion of the neural stem cell compartment. Loss- and gain-of-function experiments in the mouse cortex demonstrated that Huwe1 restrains proliferation and enables neuronal differentiation by suppressing the N-Myc-DLL3 cascade. Notably, human high-grade gliomas carry focal hemizygous deletions of the X-linked Huwe1 gene in association with amplification of the N-myc locus. Our results indicate that Huwe1 balances proliferation and neurogenesis in the developing brain and that this pathway is subverted in malignant brain tumors. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-07-07 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7947]  |
| 专题 | 昆明动物研究所_科研共享资源 |
| 作者单位 | 1.Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032 2.Department of Biomedical Informatics, Columbia University Medical Center, New York, New York 10032 3.Center for Computational Biology and Bioinformatics, Columbia University Medical Center, New York, New York 10032 4.Department of Pathology, Columbia University Medical Center, New York, New York 10032 5.Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom 6.Department of Pathology, M.D. Anderson Cancer Center, Houston, Texas 77030 7.** 8.Department of Neurology, Columbia University Medical Center, New York, New York 10032 9.Department of Pediatrics, Columbia University Medical Center, New York, New York 10032 |
| 推荐引用方式 GB/T 7714 | Zhao XD,D'Arca D,Lim WK,et al. The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain[J]. DEVELOPMENTAL CELL,2009,17(2):210-221. |
| APA | Zhao XD.,D'Arca D.,Lim WK.,Brahmachary M.,Carro MS.,...&Anna Lasorella A[*].(2009).The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain.DEVELOPMENTAL CELL,17(2),210-221. |
| MLA | Zhao XD,et al."The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain".DEVELOPMENTAL CELL 17.2(2009):210-221. |
入库方式： OAI收割
来源：昆明动物研究所
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