In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.
文献类型：期刊论文
| 作者 | Zhou, Wenna1,2; Xu, Heng1,2; Luan, Guangxiang1,2; Wang, HongLun1; Wang, Xiaoyan1; Ji, Mingkai3 |
| 刊名 | skin pharmacology and physiology
 |
| 出版日期 | 2016 |
| 卷号 | 29期号:5页码:243-249 |
| 关键词 | Caragana korshinskii Kom. Trichophyton mentagrophytes Guinea pig model Antifungal agent Histopathology |
| 英文摘要 | aim: the objective of this study was to evaluate the effects of seed oil of caragana korshinskii kom. against trichophyton mentagrophytes on an in vivo guinea pig model of dermatophytosis. methods: the skin of albino guinea pigs was infected with t. mentagrophytes, and the animals were divided into five groups: negative control (nc group), positive control (pc group), vehicle control, ck50% group (received topical 50% seed oil of c korshinskii), and ck100% group (received topical 100% seed oil of c korshinskii). evaluation of clinical efficacy was performed 72 h after the completion of a 10-day treatment regimen. skin biopsy samples were processed for histopathological examination. results: the infected untreated control guinea pigs showed patches of hair loss and ulcerated or scaly skin. lower clinical scores indicate improved efficacy compared with nc. the lesion scores significantly declined in the ck50%, ck100%, and pc groups in comparison with the nc group. the ck50% group (45.31%) and the ck100% group (75%) showed clinical efficacy compared with the pc group (78.13%). in addition, no fungal elements, inflammation, or tissue destruction was observed in any of the pas-stained sections of the infected skin in the groups treated with ck100% or 1% terbinafine. conclusion: seed oil of c. korshinskii demonstrated high antifungal efficacy in experimental dermatophytosis. (c) 2016 s. karger ag, basel |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | dermatology ; pharmacology & pharmacy |
| 研究领域[WOS] | dermatology ; pharmacology & pharmacy |
| 关键词[WOS] | microdilution method m38-a ; antifungal drugs ; dermatophytosis ; mentagrophytes ; susceptibility ; rubrum ; model ; transferrin ; quinckeanum ; efficacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000390979800002 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/6662]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, 23 Xinning Lu, Xining 810008, Qinghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Fujian Med Univ, Affiliated Hosp 1, 20 Chazhong, Fuzhou 350004, Fujian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wenna,Xu, Heng,Luan, Guangxiang,et al. In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.[J]. skin pharmacology and physiology,2016,29(5):243-249. |
| APA | Zhou, Wenna,Xu, Heng,Luan, Guangxiang,Wang, HongLun,Wang, Xiaoyan,&Ji, Mingkai.(2016).In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom..skin pharmacology and physiology,29(5),243-249. |
| MLA | Zhou, Wenna,et al."In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.".skin pharmacology and physiology 29.5(2016):243-249. |
入库方式： OAI收割
来源：西北高原生物研究所
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