Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth
文献类型：期刊论文
| 作者 | Ma, Zhinan1; Zhao, Xiaohui2; Jiang, Caiyun3; Yu, Jun4; Wu, Jiangping5; Zeng, Xin6 |
| 刊名 | journal of nanoscience and nanotechnology
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 16期号:7页码:7118-7124 |
| 关键词 | Nanoshells Apoptosis Caspase Verbascoside |
| 英文摘要 | in the present work, a new system of drug delivery to enhance the chemotherapy efficiency for cancer was established. novel core-shell structures were presented here, which were consisted of poly (n-isopropyl acrylamide) (pnipam) microspheres as cores and gold as shells. next, the chemotherapeutic agent verbascoside (vb) was combined with pnipam/gold nanoshells (gnss) structures (pms) for inducing apoptosis in drug resistant leukemia cells (k562/a02; ka). the exploration on xenografted tumors in ka nude mice indicated that anticancer drug loaded on pnipam/gnss was an efficient drug delivery vector. it induced the apoptosis of ka cells in vitro and in vivo. apoptotic staining and dna fragmentation further demonstrated that the apoptosis rate increased via the treatment of pms together with vb (vb-pms) in ka cells, compared with pms or vb treatment alone. moreover, vb-pms activated the expression of apoptosis-related caspase proteins in ka cells. in summary, a novel drug delivery system has been established, and has further been proved that the combination of vb and pms could improve therapeutic efficacy for leukemia. |
| WOS标题词 | science & technology ; physical sciences ; technology |
| 类目[WOS] | chemistry, multidisciplinary ; nanoscience & nanotechnology ; materials science, multidisciplinary ; physics, applied ; physics, condensed matter |
| 研究领域[WOS] | chemistry ; science & technology - other topics ; materials science ; physics |
| 关键词[WOS] | photothermal therapy ; fe3o4 nanoparticles ; cancer-cells ; micelles |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000387100400071 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/6667]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Yangzhou Med Univ, Yangzhou Maternal & Child Hlth Hosp, Dept Obstet & Gynecol, Yangzhou 225000, Jiangsu, Peoples R China 2.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 3.Jiangsu Engn & Res Ctr Food Safety, Jiangsu Inst Commerce, Dept Engn & Technol, Nanjing 211168, Jiangsu, Peoples R China 4.Hunan Univ Technol, Hunan Key Lab Green Packaging & Applicat Biol Nan, Zhuzhou 412007, Peoples R China 5.Nanjing Matern & Child Hlth Care Hosp, Womens Hlth Div, Nanjing 210029, Jiangsu, Peoples R China 6.Nanjing Matern & Child Hlth Care Hosp, Maternal & Child Hlth Inst, Nanjing 210029, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Zhinan,Zhao, Xiaohui,Jiang, Caiyun,et al. Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth[J]. journal of nanoscience and nanotechnology,2016,16(7):7118-7124. |
| APA | Ma, Zhinan,Zhao, Xiaohui,Jiang, Caiyun,Yu, Jun,Wu, Jiangping,&Zeng, Xin.(2016).Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth.journal of nanoscience and nanotechnology,16(7),7118-7124. |
| MLA | Ma, Zhinan,et al."Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth".journal of nanoscience and nanotechnology 16.7(2016):7118-7124. |
入库方式： OAI收割
来源：西北高原生物研究所
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