Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men
文献类型：期刊论文
| 作者 | Zheng, Zhiwei1,2 ; Li, Rui1,2,3; Xiao, Fengqiu4; He, Rongqiao5; Zhang, Shouzi6; Li, Juan1,2,3,5
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| 刊名 | FRONTIERS IN HUMAN NEUROSCIENCE
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| 出版日期 | 2017-03-06 |
| 卷号 | 11 |
| ISSN号 | 1662-5161 |
| 关键词 | associative memory sex differences hippocampus voxel-based morphometry (VBM) elderly |
| 英文摘要 | The hippocampus plays a prominent role in associative memory by supporting relational binding and recollection processes. Structural atrophy in the hippocampus is likely to induce associative memory deficits in older adults. Previous studies have primarily focused on average age-related differences in hippocampal structure and memory performance. To date, however, it remains unclear whether individual differences in hippocampal morphometry underlie differential associative memory performance, and whether there are sex differences in the structural correlates of associative memory in healthy older adults. Here, we used voxel-based morphometry (VBM) to examine the extent to which gray matter volume (GMV) of the hippocampus predicts associative memory performance in cognitively normal older adults. Seventy-one participants completed a cued recall paired-associative learning test (PALT), which consists of novel associations and semantically related associations, and underwent magnetic resonance imaging (MRI). We observed worse associative memory performance and larger variability for novel associations than for semantically related associations. The VBM results revealed that higher scores on associative memory for novel associations were related to greater hippocampal GMV across all older adults. When considering men and women separately, the correlation between hippocampal GMV and associative memory performance for novel associations reached significance only in older women. These findings suggest that hippocampal structural volumes may predict individual differences in novel associative memory in older women but not men. |
| WOS标题词 | Science & Technology ; Social Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Psychology |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychology |
| 关键词[WOS] | MEDIAL TEMPORAL-LOBE ; AGE-RELATED-CHANGES ; HEALTHY-YOUNG ADULTS ; LIFE-SPAN ; EPISODIC MEMORY ; BRAIN STRUCTURE ; ALZHEIMERS-DISEASE ; CORTICAL THICKNESS ; RECOGNITION MEMORY ; DEFICIT HYPOTHESIS |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000395434700001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/21238]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 4.China Natl Childrens Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 6.Beijing Geriatr Hosp, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Zhiwei,Li, Rui,Xiao, Fengqiu,et al. Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2017,11. |
| APA | Zheng, Zhiwei,Li, Rui,Xiao, Fengqiu,He, Rongqiao,Zhang, Shouzi,&Li, Juan.(2017).Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men.FRONTIERS IN HUMAN NEUROSCIENCE,11. |
| MLA | Zheng, Zhiwei,et al."Sex Matters: Hippocampal Volume Predicts Individual Differences in Associative Memory in Cognitively Normal Older Women but Not Men".FRONTIERS IN HUMAN NEUROSCIENCE 11(2017). |
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来源：心理研究所
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