Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes
文献类型：期刊论文
| 作者 | Wei, Guangzheng1; Tan, Dongdong1; Chen, Chunmei1; Tong, Qingyi1; Li, Xiao-Nian2; Huang, Jinfeng1; Liu, Junjun1; Xue, Yongbo1; Wang, Jianping1; Luo, Zengwei1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-02-13 |
| 卷号 | 7期号:1页码:42434 |
| 英文摘要 | Two new tetracyclic cytochalasans, flavichalasines A and B (1 and 2), three new pentacyclic cytochalasans, flavichalasines C-E (3-5), and eight new tricyclic cytochalasans, flavichalasines F-M (6-13), together with eight known analogues (14-21), were isolated from the solid culture of Aspergillus flavipes. Structures of these new compounds were elucidated on the basis of extensive spectroscopic analyses including 1D, 2D NMR and HRESIMS data. Their absolute configurations were determined by comparison of their experimental ECD with either computed ECD or experimental ECD spectrum of known compound. The structure and absolute configuration of 2 were further determined by X-ray crystallographic diffraction. Flavichalasine A (1) represents the first example of cytochalasan with a terminal double bond at the macrocyclic ring and flavichalasine E (5) is the only cytochalasan with an a-oriented oxygen-bridge in D ring. These new compounds were evaluated for their cytotoxic activities against seven human cancer cell lines, of which, 6 and 14 displayed moderate inhibitory activities against tested cell lines. In addition, compounds 6 and 14 induced apoptosis of HL60 cells by activation of caspase-3 and degradation of PARP. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | FUNGUS SPICARIA-ELEGANS ; CHAETOMIUM-GLOBOSUM ; ENDOPHYTIC FUNGUS ; CYTOTOXIC CYTOCHALASANS ; TRICHODERMA-GAMSII ; RING-SYSTEM ; ASPOCHALASIN ; CHAETOGLOBOSIN ; BIOSYNTHESIS ; METABOLITES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000394155400001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/41900]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Guangzheng,Tan, Dongdong,Chen, Chunmei,et al. Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes[J]. SCIENTIFIC REPORTS,2017,7(1):42434. |
| APA | Wei, Guangzheng.,Tan, Dongdong.,Chen, Chunmei.,Tong, Qingyi.,Li, Xiao-Nian.,...&Zhang, Yonghui.(2017).Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes.SCIENTIFIC REPORTS,7(1),42434. |
| MLA | Wei, Guangzheng,et al."Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes".SCIENTIFIC REPORTS 7.1(2017):42434. |
入库方式： OAI收割
来源：昆明植物研究所
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