Silica/organosilica cross-linked block copolymer micelles: a versatile theranostic platform
文献类型：期刊论文
| 作者 | Niu, Dechao1; Li, Yongsheng1; Shi, Jianlin1,2 |
| 刊名 | CHEMICAL SOCIETY REVIEWS
 |
| 出版日期 | 2017 |
| 卷号 | 46期号:3页码:569-585 |
| 英文摘要 | As a member of the organic-inorganic hybrid family, silica/organosilica cross-linked block copolymer micelles are becoming increasingly attractive due to the combined features of excellent self-assembly properties of amphiphilic block copolymers and the high stability and the easy surface modification of silica/organosilica components. Compared to the traditional cross-linking route with organic components, the silica/organosilica cross-linking approach could offer more advantages, such as quick reaction under mild conditions, a much stronger barrier to the diffusion of both encapsulated small molecules and functional nanoparticles and the substantial improvement in the stability of the whole micelles against the ambient environment. In this tutorial review, we will focus on the recent developments in the design, synthesis and biomedical applications of silica/organosilica cross-linked block copolymer micelles based on the self-assembly of amphiphilic block copolymers and the hydrolysis and condensation of silanes in aqueous solution. First, we will summarize the synthesis of three typical kinds of silica/organosilica cross-linked block copolymer micelles based on the self-assembly of non-ionic polyethylene oxide (PEO)-based, cationic and anionic poly(acrylic acid) (PAA)-based block copolymer micelles. Then, a series of multifunctional silica/organosilica cross-linked block copolymer micelles by encapsulating various functional nanoparticles/molecules in the hydrophobic polymer cores or hydrophilic silica/organosilica cross-linked shells are introduced and their biomedical applications in controlled drug delivery, bio-imaging (magnetic resonance, fluorescence and multimodal imaging) and imaging-guided therapies (photothermal and high intensity focused ultrasound therapies) will be discussed. Finally, the challenges and prospects of silica/organosilica cross-linked micellar nanostructures and their biological applications are discussed and assessed. It is highly expected that the silica/organosilica crosslinked micelles may provide a new and promising kind of carrier system for enhanced bio-imaging and efficient cancer therapy. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CORE-SHELL NANOPARTICLES ; FLUORESCENT CONJUGATED POLYMERS ; SILICA-BASED NANOPARTICLES ; BIOMEDICAL APPLICATIONS ; HOLLOW NANOPARTICLES ; FACILE SYNTHESIS ; IN-VIVO ; HYBRID ; NANOCAPSULES ; NANOCOMPOSITE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000395629200001 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23466]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Lab Lowdimens Mat Chem,Minist Educ, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, Dechao,Li, Yongsheng,Shi, Jianlin. Silica/organosilica cross-linked block copolymer micelles: a versatile theranostic platform[J]. CHEMICAL SOCIETY REVIEWS,2017,46(3):569-585. |
| APA | Niu, Dechao,Li, Yongsheng,&Shi, Jianlin.(2017).Silica/organosilica cross-linked block copolymer micelles: a versatile theranostic platform.CHEMICAL SOCIETY REVIEWS,46(3),569-585. |
| MLA | Niu, Dechao,et al."Silica/organosilica cross-linked block copolymer micelles: a versatile theranostic platform".CHEMICAL SOCIETY REVIEWS 46.3(2017):569-585. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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