Calcium phosphate-phosphorylated adenosine hybrid microspheres for anti-osteosarcoma drug delivery and osteogenic differentiation
文献类型：期刊论文
| 作者 | Zhou, Zi-Fei1; Sun, Tuan-Wei2; Chen, Feng2; Zuo, Dong-Qing3; Wang, Hong-Sheng3; Hua, Ying-Qi3; Cai, Zheng-Dong3; Tan, Jun1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 121页码:1-14 |
| 关键词 | Calcium phosphate Osteosarcoma Osteogenic differentiation Drug delivery Bioactivity |
| 英文摘要 | Biocompatibility, biodegradability and bioactivity are significantly important in practical applications of various biomaterials for bone tissue engineering. Herein, we develop a functional inorganic-organic hybrid system of calcium phosphate-phosphorylated adenosine (CPPA). Both calcium phosphate and phosphorylated adenosine molecules in CPPA are fundamental components in mammalians and play important roles in biological metabolism. In this work, we report our three leading research qualities: (1) CPPA hybrid microspheres with hollow and porous structure are synthesized by a facile one-step microwave-assisted solvothermal method; (2) CPPA hybrid microspheres show high doxorubicin loading capacity and pH-responsive drug release properties, and demonstrate positive therapeutic effects on six osteosarcoma cell lines in vitro and a mouse model of 143B osteosarcoma subcutaneous tumor in vivo; (3) CPPA hybrid microspheres are favorable to promote osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs) by activating the AMPK pathway, with satisfactory evidences from cellular alkaline phosphatase staining, alizarin red staining, real time PCR and western analysis. The as-prepared CPPA hybrid microspheres are promising in anti-osteosarcoma and bone regeneration, which simultaneously display excellent properties on drug delivery and osteogenic differentiation of hBMSCs. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | ACTIVATED PROTEIN-KINASE ; BONE-FORMATION ; STEM-CELLS ; MESOPOROUS MICROSPHERES ; IN-VIVO ; TISSUE ; AMP ; EXPRESSION ; MINERALIZATION ; NANOPARTICLES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000393933000001 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23467]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Tongji Univ, Shanghai East Hosp, Dept Orthoped Surg, Shanghai 200120, Peoples R China 2.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Orthoped Surg, Shanghai 200080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Zi-Fei,Sun, Tuan-Wei,Chen, Feng,et al. Calcium phosphate-phosphorylated adenosine hybrid microspheres for anti-osteosarcoma drug delivery and osteogenic differentiation[J]. BIOMATERIALS,2017,121:1-14. |
| APA | Zhou, Zi-Fei.,Sun, Tuan-Wei.,Chen, Feng.,Zuo, Dong-Qing.,Wang, Hong-Sheng.,...&Tan, Jun.(2017).Calcium phosphate-phosphorylated adenosine hybrid microspheres for anti-osteosarcoma drug delivery and osteogenic differentiation.BIOMATERIALS,121,1-14. |
| MLA | Zhou, Zi-Fei,et al."Calcium phosphate-phosphorylated adenosine hybrid microspheres for anti-osteosarcoma drug delivery and osteogenic differentiation".BIOMATERIALS 121(2017):1-14. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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