Phase-transitional Fe3O4/perfluorohexane Microspheres for Magnetic Droplet Vaporization
文献类型：期刊论文
| 作者 | Wang, Ronghui1; Zhou, Yang1; Zhang, Ping1; Chen, Yu3; Gao, Wei1; Xu, Jinshun1; Chen, Hangrong3; Cai, Xiaojun3; Zhang, Kun3; Li, Pan1 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:4页码:846-854 |
| 关键词 | Magnetic droplet vaporization Phase transition Ultrasound imaging |
| 英文摘要 | Activating droplets vaporization has become an attractive strategy for ultrasound imaging and physical therapy due to the significant increase in ultrasound backscatter signals and its ability to physically damage the tumor cells. However, the current two types of transitional droplets named after their activation methods have their respective limitations. To circumvent the limitations of these activation methods, here we report the concept of magnetic droplet vaporization (MDV) for stimuli-responsive cancer theranostics by a magnetic-responsive phase-transitional agent. This magnetic-sensitive phase-transitional agent-perfluorohexane (PFH)-loaded porous magnetic microspheres (PFH-PMMs), with high magnetic-thermal energy-transfer capability, could quickly respond to external alternating current (AC) magnetic fields to produce thermal energy and trigger the vaporization of the liquid PFH. We systematically demonstrated MDV both in vitro and in vivo. This novel trigger method with deep penetration can penetrate the air-filled viscera and trigger the vaporization of the phase-transitional agent without the need of pre-focusing lesion. This unique MDV strategy is expected to substantially broaden the biomedical applications of nanotechnology and promote the clinical treatment of tumors that are not responsive to chemical therapies. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | DRUG-DELIVERY ; IN-VIVO ; THERAPY ; ULTRASOUND ; NANOPARTICLES ; CANCER ; TUMORS ; CHEMOTHERAPY ; RELEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000396559600004 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23587]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Chongqing Med Univ, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400016, Peoples R China 2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ronghui,Zhou, Yang,Zhang, Ping,et al. Phase-transitional Fe3O4/perfluorohexane Microspheres for Magnetic Droplet Vaporization[J]. THERANOSTICS,2017,7(4):846-854. |
| APA | Wang, Ronghui.,Zhou, Yang.,Zhang, Ping.,Chen, Yu.,Gao, Wei.,...&Zheng, Yuanyi.(2017).Phase-transitional Fe3O4/perfluorohexane Microspheres for Magnetic Droplet Vaporization.THERANOSTICS,7(4),846-854. |
| MLA | Wang, Ronghui,et al."Phase-transitional Fe3O4/perfluorohexane Microspheres for Magnetic Droplet Vaporization".THERANOSTICS 7.4(2017):846-854. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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